2014年
beta-Selective C-H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I
Journal of the American Chemical Society
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- 巻
- 136
- 号
- 38
- 開始ページ
- 13226
- 終了ページ
- 13232
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/JA508449Y
- 出版者・発行元
- AMER CHEMICAL SOC
The first general beta-selective C-H arylation of pyrroles has been developed by using a rhodium catalyst. This C H arylation reaction, which is retrosynthetically straightforward but results in unusual regioselectivity, could result in de novo syntheses of pyrrole-derived natural products and pharmaceuticals. As such, we have successfully synthesized polycyclic marine pyrrole alkaloids, lamellarins C and I, by using this beta-selective arylation of pyrroles with aryl iodides (C-H/C-I coupling) and a new double C-H/C-H coupling as key steps.
- リンク情報
- ID情報
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- DOI : 10.1021/JA508449Y
- ISSN : 0002-7863
- ORCIDのPut Code : 72274783
- Web of Science ID : WOS:000342328200036