論文

査読有り 筆頭著者 責任著者
2011年7月

Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Keita Shibata
  • ,
  • Terumasa Hashimoto
  • ,
  • Koji Nobe
  • ,
  • Keiji Hasumi
  • ,
  • Kazuo Honda

384
1
開始ページ
103
終了ページ
108
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00210-011-0642-x
出版者・発行元
SPRINGER

Reactive oxygen species (ROS) formation has been found to induce the brain damage following stroke-like events. The aim of the present study was to investigate the effect of Stachybotrys microspora triprenyl phenol-7 (SMTP-7) on the generation of ROS in ischemia-induced cerebral infarction model and in vitro lipid peroxidation. We used immunohistochemistry and real-time reverse-transcription PCR for ex vivo evaluation and thiobarbituric acid-reactive substance reagent assay for in vitro evaluation. We demonstrated that SMTP-7 did not induce enhancement of 4-hydroxynonenal or neutrophil cytosolic factor 2 like t-PA administration at 3 h after ischemia ex vivo and reduce lipid peroxidation in vitro. This compound is the first low molecular weight compound with triplet activities of thrombolytic, anti-inflammatory, and antioxidant activities. We theorized that SMTP-7 is among the pharmacological agents that reduce ROS formation and have been found to limit the extent of brain damage following stroke-like events.

リンク情報
DOI
https://doi.org/10.1007/s00210-011-0642-x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000291695900008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00210-011-0642-x
  • ISSN : 0028-1298
  • eISSN : 1432-1912
  • Web of Science ID : WOS:000291695900008

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