2011年7月
Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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- 巻
- 384
- 号
- 1
- 開始ページ
- 103
- 終了ページ
- 108
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00210-011-0642-x
- 出版者・発行元
- SPRINGER
Reactive oxygen species (ROS) formation has been found to induce the brain damage following stroke-like events. The aim of the present study was to investigate the effect of Stachybotrys microspora triprenyl phenol-7 (SMTP-7) on the generation of ROS in ischemia-induced cerebral infarction model and in vitro lipid peroxidation. We used immunohistochemistry and real-time reverse-transcription PCR for ex vivo evaluation and thiobarbituric acid-reactive substance reagent assay for in vitro evaluation. We demonstrated that SMTP-7 did not induce enhancement of 4-hydroxynonenal or neutrophil cytosolic factor 2 like t-PA administration at 3 h after ischemia ex vivo and reduce lipid peroxidation in vitro. This compound is the first low molecular weight compound with triplet activities of thrombolytic, anti-inflammatory, and antioxidant activities. We theorized that SMTP-7 is among the pharmacological agents that reduce ROS formation and have been found to limit the extent of brain damage following stroke-like events.
- リンク情報
- ID情報
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- DOI : 10.1007/s00210-011-0642-x
- ISSN : 0028-1298
- eISSN : 1432-1912
- Web of Science ID : WOS:000291695900008