2000年11月
Acyl CoA Cholesteryl Acyl Transferase (ACAT) Inhibitors from Ilex spp.
Nat. Med.
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- 巻
- 54
- 号
- 6
- 開始ページ
- 297
- 終了ページ
- 305
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- 日本生薬学会
Activity-guided fractionation of a methanol extract of the leaves ofIlex kudincha, I. latifolia and I. cornuta led to the isolation of twenty-six acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory triterpenes. Nineteen of them were identified by spectroscopic methods as uvaol (1), ursolic aldehyde (2), ursolic acid (3), ursolic acid acetate (4), 23-hydroxyursolic acid (5), 2α-hydroxyuvaol (6), 11-oxoursolic acid (8), ilekudinol B methyl ester (10), 11,12-dehydroursolic acid lactone (11), ilekudinol A (13), ulmoidol (14), 27-trans-pcoumaroyloxyursolic acid (15), 3β-hydroxyolean-12-en-11-one (17), erythrodiol (18), oleanolic aldehyde (19), lupeol (21), betulin (22), ilekudinol C (23) and 30-oxolupeol (26), and seven were new compounds named ilelatifol A (7),ilecornol A methyl ester (9), ilelatifol D (12), ilelatifol C (16), ilelatifol B (20), ilekudinol D methyl ester (24) and ilekudinol E methyl ester (25). Compounds 4-7, 9-20 and 22-25 showed inhibitory activity in the ACAT assay.
- リンク情報
- ID情報
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- ISSN : 1340-3443
- CiNii Articles ID : 110008732070
- CiNii Books ID : AN10438628