論文

査読有り
2016年4月

Characteristics of fast-spiking neurons in the striatum of behaving monkeys

NEUROSCIENCE RESEARCH
  • Hiroshi Yamada
  • Hitoshi Inokawa
  • Yukiko Hori
  • Xiaochuan Pan
  • Ryuichi Matsuzaki
  • Kae Nakamura
  • Kazuyuki Samejima
  • Munetaka Shidara
  • Minoru Kimura
  • Masamichi Sakagami
  • Takafumi Minamimoto
  • 全て表示

105
105
開始ページ
2
終了ページ
18
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neures.2015.10.003
出版者・発行元
ELSEVIER IRELAND LTD

Inhibitory interneurons are the fundamental constituents of neural circuits that organize network outputs. The striatum as part of the basal ganglia is involved in reward-directed behaviors. However, the role of the inhibitory interneurons in this process remains unclear, especially in behaving monkeys. We recorded the striatal single neuron activity while monkeys performed reward-directed hand or eye movements. Presumed parvalbumin-containing GABAergic interneurons (fast-spiking neurons, FSNs) were identified based on narrow spike shapes in three independent experiments, though they were a small population (4.2%, 42/997). We found that FSNs are characterized by high-frequency and less-bursty discharges, which are distinct from the basic firing properties of the presumed projection neurons (phasically active neurons, PANs). Besides, the encoded information regarding actions and outcomes was similar between FSNs and PANs in terms of proportion of neurons, but the discharge selectivity was higher in PANs than that of FSNs. The coding of actions and outcomes in FSNs and PANs was consistently observed under various behavioral contexts in distinct parts of the striatum (caudate nucleus, putamen, and anterior striatum). Our results suggest that FSNs may enhance the discharge selectivity of postsynaptic output neurons (PANs) in encoding crucial variables for a reward-directed behavior. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.

リンク情報
DOI
https://doi.org/10.1016/j.neures.2015.10.003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375817800002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2015.10.003
  • ISSN : 0168-0102
  • eISSN : 1872-8111
  • Web of Science ID : WOS:000375817800002

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