論文

査読有り
2016年10月

Prophylactic efficacy of enteral miconazole administration for neonatal intestinal perforation and its potential mechanism

PEDIATRIC SURGERY INTERNATIONAL
  • Motofumi Torikai
  • ,
  • Satoshi Ibara
  • ,
  • Satoshi Ieiri
  • ,
  • Takashi Hamada
  • ,
  • Hiroyuki Noguchi
  • ,
  • Kazunobu Sueyoshi
  • ,
  • Takeo Fukuda
  • ,
  • Kazuhiro Abeyama

32
10
開始ページ
953
終了ページ
957
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00383-016-3946-6
出版者・発行元
SPRINGER

Intestinal perforation (IP) is a fatal complication in extremely low birth weight infants (ELBWI). We started administrating enteral miconazole (MCZ) to ELBWI in 2002. Since then, the incidence of IP has significantly decreased. The aim of this study was to elucidate the prophylactic effect of MCZ for the treatment of neonatal IP, and to establish a new prophylactic concept for this disease.
In in vivo experiments, the effects of MCZ were examined histopathologically using a mouse model of intestinal ischemia. In in vitro experiments, the cytoprotective effect of MCZ against hypoxia was evaluated using Caco-2 intestinal cells, and its anti-inflammatory potential using a co-culture model of Caco-2 and HL60 cells.
MCZ showed a tissue protective effect against intestinal ischemia. MCZ reduced high mobility group-box 1 (HMGB1) release in Caco-2 cells under hypoxic stress and attenuated the potential to activate co-cultured HL60 leukocytes with Caco-2 cells by suppressing interleukin-8 (IL-8).
MCZ may have preventive roles in the clinical management of IP in ELBWI by the suppression of IL-8 and HMGB-1.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1007/s00383-016-3946-6
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27473010
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382910200006&DestApp=WOS_CPL

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