論文

査読有り
2013年12月

Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants

PEDIATRICS INTERNATIONAL
  • Yoshinobu Maede
  • ,
  • Satoshi Ibara
  • ,
  • Hiraku Nagasaki
  • ,
  • Takeshi Inoue
  • ,
  • Takuya Tokuhisa
  • ,
  • Motofumi Torikai
  • ,
  • Chie Ishihara
  • ,
  • Takako Matsui
  • ,
  • Yuichi Kodaira

55
6
開始ページ
727
終了ページ
730
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ped.12157
出版者・発行元
WILEY-BLACKWELL

BackgroundWe conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000g.
MethodsWith a combination of enteral administration of miconazole (6mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5mg/kg/day and 3mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth.
ResultsThe prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group.
ConclusionMCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1111/ped.12157
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23773357
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000328365300018&DestApp=WOS_CPL

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