論文

国際誌
2022年3月11日

Biliary atresia: Graft-versus-host disease with maternal microchimerism as an etiopathogenesis.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • Ryuta Masuya
  • ,
  • Toshihiro Muraji
  • ,
  • Toshio Harumatsu
  • ,
  • Mitsuru Muto
  • ,
  • Kazuhiko Nakame
  • ,
  • Atsushi Nanashima
  • ,
  • Satoshi Ieiri

開始ページ
103410
終了ページ
103410
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.transci.2022.103410

Biliary atresia (BA) is an inflammatory disease of the biliary system in newborns and infants. The etiology is largely unknown. Approximately half of BA patients require liver transplantation by 20 years of age, even after surgical correction due to progressive fibrosis of the liver. Regarding the disease mechanism, there is circumstantial evidence to support the hypothesis of graft-versus-host disease because of the existence of maternal cells in the liver (maternal microchimerism, MMC), histopathological similarity of the liver and an intense maternal response to the BA patient with mixed lymphocyte culture. Immune dysregulation with decreased Treg and increased Th1 and Th17 cells are the pathogenic features of BA, which are homologous to the pathogenic features of GvHD. Further elucidation of the etiopathogenetic mechanism of BA is warranted for development of new therapeutic strategies for native liver survival.

リンク情報
DOI
https://doi.org/10.1016/j.transci.2022.103410
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35288054
ID情報
  • DOI : 10.1016/j.transci.2022.103410
  • PubMed ID : 35288054

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