論文

査読有り
2019年12月1日

Usefulness of ventilatory gas analysis for the non-invasive evaluation of the severity of chronic thromboembolic pulmonary hypertension

International Journal of Cardiology
  • Mina Akizuki
  • ,
  • Koichiro Sugimura
  • ,
  • Tatsuo Aoki
  • ,
  • Takaaki Kakihana
  • ,
  • Shunsuke Tatebe
  • ,
  • Saori Yamamoto
  • ,
  • Haruka Sato
  • ,
  • Kimio Satoh
  • ,
  • Hiroaki Shimokawa
  • ,
  • Masahiro Kohzuki

296
開始ページ
149
終了ページ
154
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ijcard.2019.07.018

© 2019 Elsevier B.V. Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organic thrombotic obstructions in the pulmonary arteries with reduced pulmonary vascular reserve. This study aimed to examine whether postural changes in ventilatory gas analysis parameters are useful for assessing pulmonary hemodynamics in patients with CTEPH. Methods: A total of 44 patients with newly diagnosed CTEPH (CTEPH group), 33 patients with improved CTEPH (mean pulmonary arterial pressure [mPAP] <25 mm Hg), and 25 controls were enrolled. Patients with improved CTEPH referred to patients without residual PH who were previously diagnosed with CTEPH and already received optimal therapies. Various pulmonary function parameters were examined in supine and sitting positions, and postural changes were calculated (Δ[supine − sitting]). In 32 patients with CTEPH, we examined hemodynamic and ventilatory gas analysis parameters before the first balloon pulmonary angioplasty (BPA) and during follow-up. Results: Patients with CTEPH had significantly lower supine end-tidal carbon dioxide pressure (PETCO2) and ΔPETCO2 than controls (both P < 0.001), and these parameters were significantly correlated with mPAP (R2 = 0.507, P < 0.0001 and R2 = 0.470, P < 0.001, respectively). Supine PETCO2 and ΔPETCO2 were significantly lower in patients with improved CTEPH than in controls (both P < 0.001). Hemodynamic and echocardiographic parameters were comparable in both groups. Furthermore, significant correlation between the change in mPAP and change in supine PETCO2 by BPA was noted (R2 = 0.478, P < 0.001). Conclusion: These results indicate that postural changes in ventilatory gas analysis parameters are useful and non-invasive method for the evaluation of mPAP, which is one of the hemodynamic parameters of CTEPH severity.

リンク情報
DOI
https://doi.org/10.1016/j.ijcard.2019.07.018
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31350036
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069682636&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85069682636&origin=inward
ID情報
  • DOI : 10.1016/j.ijcard.2019.07.018
  • ISSN : 0167-5273
  • eISSN : 1874-1754
  • PubMed ID : 31350036
  • SCOPUS ID : 85069682636

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