2015年6月
Two siblings with cortical dysplasia: Clinico-electroencephalographic features
PEDIATRICS INTERNATIONAL
- 巻
- 57
- 号
- 3
- 開始ページ
- 472
- 終了ページ
- 475
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/ped.12509
- 出版者・発行元
- WILEY-BLACKWELL
The older of two siblings began to have spasms and partial seizures at 1 month of age. Head magnetic resonance imaging showed an abnormal area in the left temporo-parieto-occipital region. Interictal electroencephalogram (EEG) showed a suppression-burst pattern. Adrenocorticotropic hormone stopped the spasms, but the seizures continued. Clonazepam, carbamazepine, zonisamide, and clobazam were ineffective. She underwent focal resection at age 8 months. Postoperatively, the seizures disappeared. Histopathologically, the lesion appeared to be focal cortical dysplasia type IIa. The younger sibling had spasms from birth. Head magnetic resonance imaging showed left hemi-megalencephaly. Interictal EEG showed a suppression-burst pattern. Phenobarbital, valproic acid, and zonisamide were ineffective. He underwent hemispherotomy at age 2 months and became seizure free. The histopathological features were consistent with those of hemi-megalencephaly. The siblings' EEG and clinical courses had some similarities. These siblings' conditions may have the same genetic background.
- リンク情報
- ID情報
-
- DOI : 10.1111/ped.12509
- ISSN : 1328-8067
- eISSN : 1442-200X
- PubMed ID : 26012518
- Web of Science ID : WOS:000356974900025