An in Vitro experiment using cultured cells was first conducted in order to analyze the influence of bone tissue collagen crosslink formation failure on osteoblast / osteoclast activity. As a result, in the cell culture system, the decrease in the amount of crosslink in the matrix increased the activity of osteoblasts and decreased the activity of osteoclasts. Serum bone formation markers increased in vivo and bone resorption markers tended to decrease. Furthermore, bone grafting experiments and implant installation experiments using an animal model of cross link formation failure resulted in bone formation around transplanted bone faster than control. A large amount of immature bone was formed around the implants earlier than the control.