Apr, 2014 - Mar, 2018
Research on the Effect of Bone Quaility (Collagen) on Bone Metabolism and Its Mechanism
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 26293408
- Japan Grant Number (JGN)
- JP26293408
- Grant amount
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- (Total)
- 15,860,000 Japanese Yen
- (Direct funding)
- 12,200,000 Japanese Yen
- (Indirect funding)
- 3,660,000 Japanese Yen
- Grant type
- Competitive
An in Vitro experiment using cultured cells was first conducted in order to analyze the influence of bone tissue collagen crosslink formation failure on osteoblast / osteoclast activity. As a result, in the cell culture system, the decrease in the amount of crosslink in the matrix increased the activity of osteoblasts and decreased the activity of osteoclasts. Serum bone formation markers increased in vivo and bone resorption markers tended to decrease. Furthermore, bone grafting experiments and implant installation experiments using an animal model of cross link formation failure resulted in bone formation around transplanted bone faster than control. A large amount of immature bone was formed around the implants earlier than the control.
- Link information
- ID information
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- Grant number : 26293408
- Japan Grant Number (JGN) : JP26293408