ツァンケム (Kam Zhang) - マイポータル

基本情報

所属: 特定国立研究開発法人理化学研究所生命機能科学研究センターチームリーダー (博士)

研究者番号: 60558906
J-GLOBAL ID: 202101012518755490
researchmap会員ID: R000023370

研究キーワード

研究分野

経歴

2018年4月 - 現在

RIKEN, Kanagawa, Japan., Center for Biosystems Dynamics Research, Team Leader
2013年4月 - 2018年3月

RIKEN, Kanagawa, Japan., Center for Life Science Technologies, Team Leader
2009年1月 - 2013年3月

RIKEN, Saitama, Japan., Advanced Science Institute, Unit Leader
2002年4月 - 2008年12月

Plexxikon, Inc., Berkeley, California, USA., Structural Biology, Director of Structural Biology
1994年11月 - 2001年6月

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Division of Basic Sciences, Assistant Member
1989年11月 - 1994年10月

University of California at Los Angeles, California, USA., Molecular Biology Institute and Department of Chemistry and Biochemistry,, Postdoctoral Research Fellow

学歴

1986年9月 - 1989年8月

University of York, Physics, PhD
1982年2月 - 1984年1月

Peking University, Chemistry, Master of Science
1978年2月 - 1982年1月

Peking University, Chemistry, Bachelor of Science

論文

117

Identification of substituted acetanilide compounds as small molecule CBX2 inhibitors via in silico screening.

Shohei Takase, Ashutosh Kumar, Sho Yokoyama, Yuki Maemoto, Komei Aoki, Mayumi Arata, Hiroki Maruo, Sayaka Dohi, Young Sook Yun, Hideshi Inoue …

Biochemical and biophysical research communications 767 151882-151882 2025年6月30日
Identification of benzimidazole-6-carboxamide based inhibitors of secretory glutaminyl cyclase for the treatment of Alzheimer's disease

K.V. Dileep, Naoki Sakai, Kentaro Ihara, Akiko Nakata, Akihiro Ito, Divya M. Sivaraman, Chi Wai Yip, Jay W. Shin, Minoru Yoshida, Mikako Shirouzu …

International Journal of Biological Macromolecules 293 139320-139320 2025年3月
A community effort in SARS-CoV-2 drug discovery.

Johannes Schimunek, Philipp Seidl, Katarina Elez, Tim Hempel, Tuan Le, Frank Noé, Simon Olsson, Lluís Raich, Robin Winter, Hatice Gokcan …

Molecular informatics 43(1) e202300262 2024年1月
Structural analysis of spike proteins from SARS-CoV-2 variants of concern highlighting their functional alterations.

Kundan Solanki, Sajjan Rajpoot, Ashutosh Kumar, Kam Y J Zhang, Tomokazu Ohishi, Nik Hirani, Khandu Wadhonkar, Pramod Patidar, Qiuwei Pan, Mirza S Baig

Future virology 2022年7月
Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2

Almasul Alfi, Aleksandr Popov, Ashutosh Kumar, Kam Y. J. Zhang, Svetlana Dubiley, Konstantin Severinov, Shunsuke Tagami

ACS Synthetic Biology 2022年6月17日査読有り
Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1.

Wei Chen, Qi Chen, Ashutosh Kumar, Xi Jiang, Kam Y J Zhang, Qing Yang

Journal of enzyme inhibition and medicinal chemistry 36(1) 1198-1204 2021年12月
Corrigendum to “Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2” [Microbial Pathog. 145 (2020) 104236](S0882401020305234)(10.1016/j.micpath.2020.104236)

Parismita Kalita, Aditya K. Padhi, Kam Y.J. Zhang, Timir Tripathi

Microbial Pathogenesis 160 2021年11月1日
Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.

Sota Yagi, Aditya K Padhi, Jelena Vucinic, Sophie Barbe, Thomas Schiex, Reiko Nakagawa, David Simoncini, Kam Y J Zhang, Shunsuke Tagami

Journal of the American Chemical Society 143(39) 15998-16006 2021年9月24日
ProFitFun: A Protein Tertiary Structure Fitness Function for Quantifying the Accuracies of Model Structures.

Rahul Kaushik, Kam Y J Zhang

Bioinformatics (Oxford, England) 2021年9月20日
Evolutionary Signatures Governing the Codon Usage Bias in Coronaviruses and Their Implications for Viruses Infecting Various Bat Species.

Naveen Kumar, Rahul Kaushik, Chandana Tennakoon, Vladimir N Uversky, Anamika Mishra, Richa Sood, Pratiksha Srivastava, Meghna Tripathi, Kam Y J Zhang, Sandeep Bhatia

Viruses 13(9) 2021年9月16日
A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2 Receptor.

Sajjan Rajpoot, Tomokazu Ohishi, Ashutosh Kumar, Qiuwei Pan, Sreeparna Banerjee, Kam Y J Zhang, Mirza S Baig

Drugs in R&D 21(3) 273-283 2021年9月
An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes.

Aditya K Padhi, Ashutosh Kumar, Ken-Ichi Haruna, Haruna Sato, Hiroko Tamura, Satoru Nagatoishi, Kouhei Tsumoto, Atushi Yamaguchi, Fumie Iraha, Mihoko Takahashi …

Briefings in bioinformatics 22(6) 2021年8月20日
A comprehensive characterization of novel CYP-BM3 homolog (CYP-BA) from Bacillus aryabhattai.

Sourya Bhattacharya, Abhilek K Nautiyal, Rajanya Bhattacharjee, Aditya K Padhi, Vivek Junghare, Muskaan Bhambri, Diptarka Dasgupta, Kam Y J Zhang, Debasish Ghosh, Saugata Hazra

Enzyme and microbial technology 148 109806-109806 2021年8月
Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation.

Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff, Veer Gupta, Angela Godinez, Danit Saks, Soumalya Sarkar, Ting Shen, Mehdi Mirzaei, Devaraj Basavarajappa …

Cells 10(8) 2021年7月31日
A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain.

Shabeesh Balan, Yoshimi Iwayama, Tetsuo Ohnishi, Mikiko Fukuda, Atsuko Shirai, Ayumi Yamada, Sara Weirich, Maren Kirstin Schuhmacher, Kalarickal Vijayan Dileep, Toshihiro Endo …

Molecular psychiatry 26(12) 7550-7559 2021年7月15日
A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.

Motoi Yamashita, Hye Sun Kuehn, Kazuki Okuyama, Satoshi Okada, Yuzaburo Inoue, Noriko Mitsuiki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Masahiro Takeuchi …

Nature immunology 22(7) 893-903 2021年7月
Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.

Mutsuko Kukimoto-Niino, Kazushige Katsura, Rahul Kaushik, Haruhiko Ehara, Takeshi Yokoyama, Tomomi Uchikubo-Kamo, Reiko Nakagawa, Chiemi Mishima-Tsumagari, Mayumi Yonemochi, Mariko Ikeda …

Science advances 7(30) 2021年7月
Identification of 1,2,4-triazolylthioethanone Scaffold for the Design of New Acetylcholinesterase Inhibitors.

Erma Fatiha Muhammad, Ashutosh Kumar, Habibah A Wahab, Kam Y J Zhang

Molecular informatics 40(8) e2100020 2021年6月1日
Lean-Docking: Exploiting Ligands' Predicted Docking Scores to Accelerate Molecular Docking.

Francois Berenger, Ashutosh Kumar, Kam Y J Zhang, Yoshihiro Yamanishi

Journal of chemical information and modeling 61(5) 2341-2352 2021年5月24日
Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins.

Naveen Kumar, Rahul Kaushik, Chandana Tennakoon, Vladimir N Uversky, Sonia Longhi, Kam Y J Zhang, Sandeep Bhatia

Journal of proteome research 20(5) 2704-2713 2021年5月7日

もっとみる

MISC

Targeting LIF/LIFR signaling in cancer

Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi

Genes and Diseases 2021年

共同研究・競争的資金等の研究課題

非天然アミノ酸の取り込みによる安定かつ高親和性の治療用ナノボディの設計

日本学術振興会科学研究費助成事業特別研究員奨励費 2018年10月 - 2021年3月

ZHANG KAM, PADHI ADITYA
タンパク質の構造設計の計算方法の研究開発および実験検証

日本学術振興会科学研究費助成事業基盤研究(B) 2018年4月 - 2021年3月

ZHANG KAM
アルツハイマー病治療のためのヒトグルタミニルシクラーゼ阻害剤の探索

日本学術振興会科学研究費助成事業特別研究員奨励費 2016年11月 - 2019年3月

ZHANG KAM, VIJAYAN DILEEP

ツァンケム

基本情報

研究キーワード

研究分野

経歴

学歴

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

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