Kan Saiga - My portal

Profile Information

Affiliation: Tokyo Women's Medical University

J-GLOBAL ID: 201801002113688883
researchmap Member ID: B000309367

Research Areas

Life sciences / Immunology /

Papers

Novel Complement C5 Small-interfering RNA Lipid Nanoparticle Prolongs Graft Survival in a Hypersensitized Rat Kidney Transplant Model.

Hidetoshi Ishigooka, Haruki Katsumata, Kan Saiga, Daisuke Tokita, Sotaro Motoi, Chiyuki Matsui, Yuta Suzuki, Ayaka Tomimatsu, Tomoya Nakatani, Yoshikazu Kuboi …

Transplantation, Jun 24, 2022
Role of Fractalkine-CX3CR1 Axis in Acute Rejection of Mouse Heart Allografts Subjected to Ischemia Reperfusion Injury.

Taichi Kanzawa, Daisuke Tokita, Kan Saiga, Takafumi Yamakawa, Hidetoshi Ishigooka, Hironori Fukuda, Haruki Katsumata, Satoshi Miyairi, Rumi Ishii, Toshihito Hirai …

Transplant international : official journal of the European Society for Organ Transplantation, 35 10157-10157, 2022
Involvement of non‑triple helical type VI collagen α1 chain, NTH α1(VI), in the proliferation of cancer cells.

Takamichi Sato, Kazuhiro Tokunaka, Kan Saiga, Arihiro Tomura, Hidemitsu Sugihara, Toshihiko Hayashi, Yasutada Imamura, Makoto Morita

Oncology reports, 44(5) 2297-2305, Nov, 2020 Peer-reviewed
Triazolopyrimidine derivative NK026680 and donor-specific transfusion induces CD4+CD25+Foxp3+ T cells and ameliorates allograft rejection in an antigen-specific manner.

Shin Emoto, Susumu Shibasaki, Akihisa Nagatsu, Ryoichi Goto, Hitoshi Ono, Yasutomo Fukasaku, Rumi Igarashi, Takuji Ota, Moto Fukai, Tsuyoshi Shimamura …

Transplant immunology, 65 101338-101338, Oct 3, 2020 Peer-reviewed
α-ガラクトシルセラミドとラパマイシンの併用による移植免疫寛容誘導の検証

山川貴史, 神澤太一, 石井瑠美, 雑賀寛, 石井保之, 奥見雅由, 横尾隆, 田邉一成

日本腎臓学会誌, 62(4) 360-360, Jul, 2020
虚血再灌流障害関連拒絶反応におけるフラクタルカイン-CX3CR1シグナルに関する研究

神澤太一, 時田大輔, 山川貴史, 石郷岡秀俊, 福田洋典, 勝俣陽貴, 宮入聡, 石井瑠美, 平井敏仁, 雑賀寛 …

移植, 54(総会臨時) 264-264, Sep, 2019
Combination therapy of an iNKT cell ligand and CD40-CD154 blockade establishes islet allograft acceptance in nonmyeloablative bone marrow transplant recipients.

Taichi Kanzawa, Toshihito Hirai, Hironori Fukuda, Haruki Katsumata, Rumi Ishii, Masako Ikemiyagi, Yasuyuki Ishii, Kan Saiga, Masayoshi Okumi, Kazunari Tanabe

Acta diabetologica, 56(5) 541-550, May, 2019 Peer-reviewed
Identification of a common epitope in the sequences of COL4A1 and COL6A1 recognised by monoclonal antibody #141.

Sato T, Takano R, Takahara N, Tokunaka K, Saiga K, Tomura A, Sugihara H, Hayashi T, Imamura Y, Morita M

J Biochem., 165(1) 85-95, Jan, 2019 Peer-reviewed
Evaluation of the impact of conventional immunosuppressant on the establishment of murine transplantation tolerance - an experimental study.

Katsumata H, Miyairi S, Ikemiyagi M, Hirai T, Fukuda H, Kanzawa T, Ishii R, Saiga K, Ishii Y, Omoto K …

Transpl Int, Dec, 2018 Peer-reviewed
Impact of Activated Invariant Natural Killer T Cells on the Expansion of Regulatory T Cell Precursors in Murine Thymocytes In Vitro.

Katsumata H, Ikemiyagi M, Hirai T, Kanzawa T, Ishii R, Miyairi S, Fukuda H, Saiga K, Okumi M, Ishii Y …

Immunol Lett., Nov, 2018 Peer-reviewed
Long-lasting immunosuppressive effects of tacrolimus-loaded micelle NK61060 in preclinical arthritis and colitis models.

Sato T, Konno J, Sekiguchi A, Yoneki N, Kawano K, Hayashi T, Ogawa Y, Kikitsu A, Aijima T, Hara K …

Ther Deliv., 9(10) 711-729, Oct, 2018 Peer-reviewed
Type VI collagen α1 chain polypeptide in non-triple helical form is an alternative gene product of COL6A1.

Sato T, Takano R, Tokunaka K, Saiga K, Tomura A, Sugihara H, Hayashi T, Imamura Y, Morita M

J Biochem., 164(2) 173-181, Aug, 2018 Peer-reviewed
Preparation and partial characterization of monoclonal antibodies specific for the nascent non-triple helical form of the type IV collagen alpha 1 chain

Makoto Morita, Hidemitsu Sugihara, Kazuhiro Tokunaka, Arihiro Tomura, Kan Saiga, Takamichi Sato, Yasutada Imamura, Toshihiko Hayashi

Biochemistry and Biophysics Reports, 9 128-132, Mar 1, 2017 Peer-reviewed
Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis

Junichi Hirahashi, Kimito Kawahata, Makoto Arita, Ryo Iwamoto, Keiichi Hishikawa, Mie Honda, Yoshifumi Hamasaki, Mototsugu Tanaka, Koshu Okubo, Miho Kurosawa …

SCIENTIFIC REPORTS, 4 6406, Sep, 2014 Peer-reviewed
Direct activation of glomerular endothelial cells by anti-moesin activity of anti-myeloperoxidase antibody

Tomokazu Nagao, Koya Suzuki, Kentaro Utsunomiya, Mimiko Matsumura, Kan Saiga, Pi-Chao Wang, Haruyuki Minamitani, Yasuaki Aratani, Toshinori Nakayama, Kazuo Suzuki

NEPHROLOGY DIALYSIS TRANSPLANTATION, 26(9) 2752-2760, Sep, 2011 Peer-reviewed
Reduction of MPO-ANCA epitopes in SCG/Kj mice by 15-deoxyspergualin treatment restricted by IgG2b associated with crescentic glomerulonephritis

Kazuo Tomizawa, Tomokazu Nagao, Reina Kusunoki, Kan Saiga, Masamichi Oshima, Kazuo Kobayashi, Toshinori Nakayama, Masaru Tanokura, Kazuo Suzuki

RHEUMATOLOGY, 49(7) 1245-1256, Jul, 2010 Peer-reviewed
Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice

Ming-Cai Zhang, Hiroshi Furukawa, Kazuhiro Tokunaka, Kan Saiga, Fumiko Date, Yuji Owada, Masato Nose, Masao Ono

IMMUNOGENETICS, 60(10) 599-607, Oct, 2008 Peer-reviewed
Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice

Kan Saiga, Minako Yoshida, Iwao Nakamura, Eriko Toyoda, Kazuhiro Tokunaka, Hirohisa Morohashi, Fuminori Abe, Kyuichi Nemoto, Masato Nose

INTERNATIONAL IMMUNOPHARMACOLOGY, 8(9) 1183-1189, Sep, 2008 Peer-reviewed
Expansion of p75NTR/Oct4 expressing putative stem cells in HPV16-transformed precancerous immortal cell lines under the presence of TGFβ and TNFα

Saiga K, Takeuchi M, Kikuchi K, Morimura S, Kiguchi K, Yasumoto S

The Open Biotechnology Journal, 2 121-132, Feb, 2008 Peer-reviewed
NK026680, a novel suppressant of dendritic cell function, prevents the development of rapidly progressive glomerulonephritis and perinuclear antineutrophil cytoplasmic antibody in SCG/Kj mice

Kan Saiga, Kazuhiro Tokunaka, Eiji Ichimura, Eriko Toyoda, Fuminori Abe, Minako Yoshida, Hiroshi Furukawa, Masato Nose, Masao Ono

ARTHRITIS AND RHEUMATISM, 54(11) 3707-3715, Nov, 2006 Peer-reviewed

Misc.

虚血再灌流障害関連拒絶反応におけるフラクタルカイン-CX3CR1シグナルに関する研究

神澤太一, 時田大輔, 山川貴史, 石郷岡秀俊, 福田洋典, 勝俣陽貴, 宮入聡, 石井瑠美, 平井敏仁, 雑賀寛 …

移植, 54(総会臨時) 264-264, Sep, 2019
Single-chain type IV collagen (SCCOL-IV), an alternative gene product of COL4A1 as a therapeutic target in tumor tissue expansion as well as a diagnostic marker

Kazuhiro Tokunaka, Arihiro Tomura, Takamichi Sato, Kan Saiga, Chieko Seno, Hidemitsu Sugihara, Yasutada Imamura, Toshihiko Hayashi, Makoto Morita

CANCER RESEARCH, 71, Apr, 2011
Risk epitopes of MPO-ANCA in SCG/Kj mice

Kazuo Tomizawa, Tomokazu Nagao, Kan Saiga, Masamichi Oshima, Kazuo Kobayashi, Toshinori Nakayama, Masaru Tanokura, Kazuo Suzuki

APMIS, 117 168-168, Jun, 2009
Role of activated neutrophils in spontaneously crescentic glomerulonephritis forming (SCG/Kj) mice.

T Ito-Ihara, A Ishida-Okawara, E Muso, T Ono, K Saiga, K Suzuki

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 13 175A-175A, Sep, 2002
Development of MPO-ANCA precedes glomerular endocapillary neutrophil influx followed by crescent formation in spontaneous crescentic glomerulonephritis (SCG) mice.

S Miyazawa, K Saiga, O Hotta, T Mae, K Nemoto, T Oda, Y Taguma, T Saito

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 8 A2140-A2140, Sep, 1997

Books and Other Publications

各疾患モデル動物の作製と病態・薬効評価

雑賀寛 (Role: Contributor, 第11節糸球体腎炎)

技術情報協会