2019年
Tau isoform expression and phosphorylation in marmoset brains
Journal of Biological Chemistry
- 巻
- 294
- 号
- 30
- 開始ページ
- 11433
- 終了ページ
- 11444
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1074/jbc.RA119.008415
- 出版者・発行元
- Journal of Biological Chemistry
© 2019 Sharma et al. Tau is a microtubule-associated protein expressed in neuronal axons. Hyperphosphorylated tau is a major component of neurofibrillary tangles, a pathological hallmark of Alzheimer’s disease (AD). Hyperphosphorylated tau aggregates are also found in many neurodegenerative diseases, collectively referred to as “tauopathies,” and tau mutations are associated with familial frontotemporal lobar degeneration (FTLD). Previous studies have generated transgenic mice with mutant tau as tauopathy models, but nonhuman primates, which are more similar to humans, may be a better model to study tauopathies. For example, the common marmoset is poised as a nonhuman primate model for investigating the etiology of age-related neurodegenerative diseases. However, no biochemical studies of tau have been conducted in marmoset brains. Here, we investigated several important aspects of tau, including expression of different tau isoforms and its phosphorylation status, in the marmoset brain. We found that marmoset tau does not possess the “primate-unique motif” in its N-terminal domain. We also discovered that the tau isoform expression pattern in marmosets is more similar to
- リンク情報
- ID情報
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- DOI : 10.1074/jbc.RA119.008415
- ISSN : 0021-9258
- PubMed ID : 31171723
- PubMed Central 記事ID : PMC6663862