論文

国際誌
2019年

Tau isoform expression and phosphorylation in marmoset brains

Journal of Biological Chemistry
  • Sharma G
  • Huo A
  • Kimura T
  • Shiozawa S
  • Kobayashi R
  • Sahara N
  • Ishibashi M
  • Ishigaki S
  • Saito T
  • Ando K
  • Murayama S
  • Hasegawa M
  • Sobue G
  • Okano H
  • Hisanaga S
  • 全て表示

294
30
開始ページ
11433
終了ページ
11444
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1074/jbc.RA119.008415
出版者・発行元
Journal of Biological Chemistry

© 2019 Sharma et al. Tau is a microtubule-associated protein expressed in neuronal axons. Hyperphosphorylated tau is a major component of neurofibrillary tangles, a pathological hallmark of Alzheimer’s disease (AD). Hyperphosphorylated tau aggregates are also found in many neurodegenerative diseases, collectively referred to as “tauopathies,” and tau mutations are associated with familial frontotemporal lobar degeneration (FTLD). Previous studies have generated transgenic mice with mutant tau as tauopathy models, but nonhuman primates, which are more similar to humans, may be a better model to study tauopathies. For example, the common marmoset is poised as a nonhuman primate model for investigating the etiology of age-related neurodegenerative diseases. However, no biochemical studies of tau have been conducted in marmoset brains. Here, we investigated several important aspects of tau, including expression of different tau isoforms and its phosphorylation status, in the marmoset brain. We found that marmoset tau does not possess the “primate-unique motif” in its N-terminal domain. We also discovered that the tau isoform expression pattern in marmosets is more similar to

リンク情報
DOI
https://doi.org/10.1074/jbc.RA119.008415
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31171723
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663862
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070096927&origin=inward
ID情報
  • DOI : 10.1074/jbc.RA119.008415
  • ISSN : 0021-9258
  • PubMed ID : 31171723
  • PubMed Central 記事ID : PMC6663862

エクスポート
BibTeX RIS