2017年8月
Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
SCIENTIFIC REPORTS
- 巻
- 7
- 号
- 1
- 開始ページ
- 7883
- 終了ページ
- 7883
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-017-07949-4
- 出版者・発行元
- NATURE PUBLISHING GROUP
Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother's milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1-7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed. In adult mice, plasma OT was also increased in a RAGE-dependent manner after oral delivery or direct administration into the intestinal tract. Mass spectrometry evaluated that OT was absorbed intact. RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults. These data highlight that OT is transmitted via a receptor-mediated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug development.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41598-017-07949-4
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28801574
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554167
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000407442500023&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/s41598-017-07949-4
- ISSN : 2045-2322
- PubMed ID : 28801574
- PubMed Central 記事ID : PMC5554167
- Web of Science ID : WOS:000407442500023