論文

査読有り 本文へのリンクあり 国際誌
2019年12月1日

Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice

Communications Biology
  • Yasuhiko Yamamoto
  • ,
  • Mingkun Liang
  • ,
  • Seiichi Munesue
  • ,
  • Kisaburo Deguchi
  • ,
  • Ai Harashima
  • ,
  • Kazumi Furuhara
  • ,
  • Teruko Yuhi
  • ,
  • Jing Zhong
  • ,
  • Shirin Akther
  • ,
  • Hisanori Goto
  • ,
  • Yuya Eguchi
  • ,
  • Yasuko Kitao
  • ,
  • Osamu Hori
  • ,
  • Yoshitake Shiraishi
  • ,
  • Noriyuki Ozaki
  • ,
  • Yu Shimizu
  • ,
  • Tomoya Kamide
  • ,
  • Akifumi Yoshikawa
  • ,
  • Yasuhiko Hayashi
  • ,
  • Mitsutoshi Nakada
  • ,
  • Olga Lopatina
  • ,
  • Maria Gerasimenko
  • ,
  • Yulia Komleva
  • ,
  • Natalia Malinovskaya
  • ,
  • Alla B. Salmina
  • ,
  • Masahide Asano
  • ,
  • Katsuhiko Nishimori
  • ,
  • Steven E. Shoelson
  • ,
  • Hiroshi Yamamoto
  • ,
  • Haruhiro Higashida

2
1
開始ページ
76
終了ページ
76
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-019-0325-6

© 2019, The Author(s). Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt−/−, Cd38−/−) or its receptor (Oxtr−/−) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt−/− and Cd38−/−, but not Oxtr−/− mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The increases in oxcytocin in the brain which follow exogenous administration are lost in Ager−/− male mice lacking RAGE, and behaviours characteristic to abnormalities in oxcytocin signalling are recapitulated in Ager−/− mice, including deficits in maternal bonding and hyperactivity. Our findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding.

リンク情報
DOI
https://doi.org/10.1038/s42003-019-0325-6
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30820471
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389896
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066252161&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85066252161&origin=inward
ID情報
  • DOI : 10.1038/s42003-019-0325-6
  • eISSN : 2399-3642
  • PubMed ID : 30820471
  • PubMed Central 記事ID : PMC6389896
  • SCOPUS ID : 85066252161

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