論文

国際誌
2019年7月1日

Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex.

The Journal of comparative neurology
  • Minkyung Shin
  • ,
  • Ayako Kitazawa
  • ,
  • Satoshi Yoshinaga
  • ,
  • Kanehiro Hayashi
  • ,
  • Yukio Hirata
  • ,
  • Colette Dehay
  • ,
  • Ken-Ichiro Kubo
  • ,
  • Kazunori Nakajima

527
10
開始ページ
1577
終了ページ
1597
記述言語
英語
掲載種別
DOI
10.1002/cne.24634
出版者・発行元
Journal of Comparative Neurology

During development of the mammalian cerebral neocortex, postmitotic excitatory neurons migrate toward the outermost region of the neocortex. We previously reported that this outermost region is composed of densely packed relatively immature neurons; we named this region, which is observed during the late stage of mouse neocortical development, the "primitive cortical zone (PCZ)." Here, we report that postmigratory immature neurons spend about 1-1.5 days in the PCZ. An electron microscopic analysis showed that the neurons in the PCZ tend to be in direct contact with each other, mostly in a radial direction, forming "primitive neuronal clusters" with a height of 3-7 cells and a width of 1-2 cells. A time-course analysis of fluorescently labeled neurons revealed that the neurons took their positions within the primitive clusters in an inside-out manner. The neurons initially participated in the superficial part of the clusters, gradually shifted their relative positions downward, and then left the clusters at the bottom of this structure. GABAergic inhibitory interneurons were also found within the primitive clusters in the developing mouse neocortex, suggesting that some clusters are composed of both excitatory neurons and inhibitory interneurons. Similar clusters were also observed in the outermost region of embryonic day (E) 78 cynomolgus monkey occipital cortex and 23 gestational week (GW) human neocortices. In the primate neocortices, including human, the presumptive primitive clusters seemed to expand in the radial direction more than that observed in mice, which might contribute to the functional integrity of the primate neocortex.

リンク情報
DOI
https://doi.org/10.1002/cne.24634
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30636008
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061038699&origin=inward

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