1998年3月
Involvement of dendritic adhesion molecule telencephalin in hippocampal long-term potentiation
NEUROREPORT
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- 巻
- 9
- 号
- 5
- 開始ページ
- 881
- 終了ページ
- 886
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/00001756-199803300-00022
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
TELENCEPHALIN (TLCN) is a cell adhesion molecule belonging to the immunoglobulin superfamily whose expression is restricted to neurons within the most highly developed brain segment, telencephalon. Immunoelectronmicroscopic study revealed that in the hippocampal CA1 region, TLCN was localized at the surface membrane of postsynaptic spines of pyramidal cell dendrites but not at that of axonal terminals. Blocking of TLCN function using anti-TLCN antibody or recombinant soluble TLCN protein caused a striking suppression of the long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses. The suppression was observed even when the blocking was initiated immediately after the tetanic stimuli. These observations suggest a role for TLCN-mediated cell-cell interactions as a key step in the development of LTP. (C) 1998 Rapid Science Ltd.
- リンク情報
- ID情報
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- DOI : 10.1097/00001756-199803300-00022
- ISSN : 0959-4965
- PubMed ID : 9579684
- Web of Science ID : WOS:000072808900022