2020年8月
Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke
Journal of Pharmacological Sciences
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- 巻
- 144
- 号
- 3
- 開始ページ
- 183
- 終了ページ
- 188
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jphs.2020.07.012
- 出版者・発行元
- Elsevier BV
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jphs.2020.07.012
- ISSN : 1347-8613
- PubMed ID : 32807663