2015年12月
Stereoselective Synthesis of Z-α,β-Unsaturated Sulfones Using Peterson Reagents
Organic Letters
- ,
- ,
- ,
- 巻
- 17
- 号
- 24
- 開始ページ
- 6026
- 終了ページ
- 6029
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.5b03008
© 2015 American Chemical Society. New Peterson reagents were prepared by introducing alkyloxy groups on the silicon atom in order to fix the conformation of the sulfone anion. The reagents 1d and 1e reacted with a variety of aldehydes after the treatment with Li-base to give Z-α,β-unsaturated sulfones with up to >99:1 selectivity in good to excellent yields. For the reaction with aliphatic aldehydes, CPME (cyclopentyl methyl ether) is the choice of solvent, while DME (1,2-dimethoxyethane) gave higher selectivity for the reaction with aromatic aldehydes.
- リンク情報
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- DOI
- https://doi.org/10.1021/acs.orglett.5b03008
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000366878300023&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84952650385&origin=inward
- ID情報
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- DOI : 10.1021/acs.orglett.5b03008
- ISSN : 1523-7060
- eISSN : 1523-7052
- Web of Science ID : WOS:000366878300023