論文

査読有り
2016年

Comparative Study of Infliximab Therapy and Methotrexate Monotherapy to Improve the Clinical Effect in Rheumatoid Arthritis Patients

INTERNAL MEDICINE
  • Yusuke Miwa
  • ,
  • Sakiko Isojima
  • ,
  • Mayu Saito
  • ,
  • Yuzo Ikari
  • ,
  • Mika Kobuna
  • ,
  • Tomoki Hayashi
  • ,
  • Ryo Takahashi
  • ,
  • Tsuyoshi Kasama
  • ,
  • Michio Hosaka
  • ,
  • Kenji Sanada

55
18
開始ページ
2581
終了ページ
2585
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.55.6872
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Objective We examined whether infliximab (IFX) therapy was more effective than methotrexate (MTX) monotherapy to achieve an improvement in depressive states in Rheumatoid Arthritis (RA) patients.
Methods We examined 152 RA patients (72 IFX patients and 80 MTX patients). We conducted an open-label cohort study to evaluate the disease activity of RA (Simplified Disease Activity Index; SDAI), depressive states (Hamilton Rating Scale for Depression; HAM-D), Activity of Daily Living (ADL) (modified Health Assessment Questionnaire; mHAQ) and Quality of Life (QOL) [ Short Form (SF)-36] in patients before and 6 months after receiving therapy. The HAM-D, SDAI, mHAQ and SF-36 scores after 6 months of therapy were measured as the outcomes.
Results We analyzed 60 IFX patients and 53 MTX patients. The HAM-D scores significantly improved in both groups (p<0.001), but there was no significant difference in the effectiveness between the IFX and MTX therapies (p=0.792). The SDAI scores significantly improved in both groups after therapy (p<0.001), and IFX therapy was more effective than MTX therapy (p=0.004). The mHAQ and HAM-D scores also improved significantly in both groups after therapy (p<0.001), but no significant difference in the effectiveness between the IFX and MTX therapies was observed (p=0.272, 0.792). The scores of all 8 items of the SF-36 improved in both groups after therapy, but IFX therapy was more effective than MTX therapy in only 4 of the 8 items (p<0.05).
Conclusion Both IFX and MTX therapy improved the clinical efficacy, ADL, QOL and depressive states. However, no significant differences regarding an improvement in the depressive states and ADL were observed between IFX therapy and MTX monotherapy.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.55.6872
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27629950
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000384663200008&DestApp=WOS_CPL
ID情報
  • DOI : 10.2169/internalmedicine.55.6872
  • ISSN : 0918-2918
  • eISSN : 1349-7235
  • PubMed ID : 27629950
  • Web of Science ID : WOS:000384663200008

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