論文

査読有り
2014年5月16日

Serum anticyclic citrullinated protein antibody titers are correlated with the response to biological agents in patients with rheumatoid arthritis

Open Access Rheumatology: Research and Reviews
  • Ryo Takahashi
  • ,
  • Sakiko Isojima
  • ,
  • Masayu Umemura
  • ,
  • Yoko Miura
  • ,
  • Nao Oguro
  • ,
  • Syo Ishii
  • ,
  • Shinya Seki
  • ,
  • Takahiro Tokunaga
  • ,
  • Hiroyuki Tsukamoto
  • ,
  • Hidekazu Furuya
  • ,
  • Ryo Yanai
  • ,
  • Tsuyoshi Kasama

6
開始ページ
57
終了ページ
64
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2147/OARRR.S58772
出版者・発行元
Dove Medical Press Ltd

Anticyclic citrullinated protein antibody (ACPA) is known as an important indicator for diagnosis of rheumatoid arthritis (RA). Our aim was to examine the relationship between the serum ACPA titer at baseline and responsiveness to biological agents (antagonists of either tumor necrosis factor or interleukin 6) in patients with RA. ACPA was measured using second-generation chemiluminescent enzyme immunoassay. Disease activity was assessed using disease activity scores 28. Fifty-seven RA patients with biological agents were enrolled, and the median ACPA titer at baseline was 110.0 U/mL. The median ACPA titer was 23.3 U/mL and 183.0 U/mL in the good and moderate response groups, respectively, which were significantly lower than in the no response group (404.0 U/mL). In addition, 69.2% and 26.9% of patients with low (&lt
100 U/mL) and moderate (100-499 U/mL) basal ACPA titers showed a moderate to good response. Of the patients with higher (≥500 U/mL) basal ACPA titers, only 14.0% and 42.5% showed a good or moderate response, respectively. The remission rate was 77.8% in the ACPA-negative, which was significantly higher than the rate of 25% in the ACPA-positive patients. The results suggest that the ACPA titers are correlated with the efficacy of the biological agents used in patients with RA. © 2014 Takahashi et al.

リンク情報
DOI
https://doi.org/10.2147/OARRR.S58772
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27790035
ID情報
  • DOI : 10.2147/OARRR.S58772
  • ISSN : 1179-156X
  • PubMed ID : 27790035
  • SCOPUS ID : 84901321425

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