論文

査読有り
2014年3月

Serum macrophage migration inhibitory factor levels are correlated with response to tocilizumab therapy in patients with rheumatoid arthritis

RHEUMATOLOGY INTERNATIONAL
  • Tsuyoshi Kasama
  • ,
  • Sakiko Isojima
  • ,
  • Masayu Umemura
  • ,
  • Hiroyuki Tsukamoto
  • ,
  • Takehiro Tokunaga
  • ,
  • Hidekazu Furuya
  • ,
  • Ryo Yanai
  • ,
  • Ryo Takahashi
  • ,
  • Masanori Nakamura
  • ,
  • Katsunori Inagaki

34
3
開始ページ
429
終了ページ
433
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00296-013-2778-0
出版者・発行元
SPRINGER HEIDELBERG

To examine the relationship between serum cytokine levels and response to tocilizumab in patients with RA. The disease status of 21 RA patients was assessed at baseline and after 12 weeks of tocilizumab treatment, using the clinical disease activity index (CDAI). Clinical response to tocilizumab was defined as an improvement of > 50 % from the baseline CDAI. Serum cytokine levels were quantified using double-ligand ELISA for TNF-alpha, IL-6, CCL2, CCL3, CXCL8, CXCL10, CX3CL1, and macrophage migration inhibitory factor (MIF). After 12 weeks of tocilizumab treatment, there was a significant overall reduction in RA disease activity (CDAI), from 22.4 +/- A 11.3 to 9.2 +/- A 6.6 (p < 0.0001), across the entire patient group. After 12 weeks of tocilizumab treatment, 14 patients achieved a > 50 % improvement (the responder group), but there were no significant responses in the other 7 patients (the non-responder group). The erythrocyte sedimentation rate levels, the positive % of anti-cyclic citrullinated protein antibody and patients (%) receiving methotrexate in combination with tocilizumab were significantly higher in the responder group than in the non-responder group. Although serum baseline levels of CCL2 and CXCL8 were higher in the responder group than in the non-responder group, there were no significant changes in these chemokine levels after treatment. The serum MIF levels, but not the levels of other cytokines, in the responder group were significantly decreased after tocilizumab treatment. Our results suggest that tocilizumab differentially regulates serum cytokine profiles in patients with RA, and MIF regulation in patients with active RA may be sensitive to anti-IL-6 therapy.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1007/s00296-013-2778-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23670804
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000331832500020&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00296-013-2778-0
  • ISSN : 0172-8172
  • eISSN : 1437-160X
  • PubMed ID : 23670804
  • Web of Science ID : WOS:000331832500020

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