論文

査読有り 最終著者 責任著者 国際誌
2021年10月

Differentiation of THP-1 monocytes to macrophages increased mitochondrial DNA copy number but did not increase expression of mitochondrial respiratory proteins or mitochondrial transcription factor A

Archives of Biochemistry and Biophysics
  • Mizuho Okamoto
  • ,
  • Masanori Shimogishi
  • ,
  • Akari Nakamura
  • ,
  • Yusuke Suga
  • ,
  • Kyosuke Sugawara
  • ,
  • Michio Sato
  • ,
  • Ryotaro Nishi
  • ,
  • Akio Fujisawa
  • ,
  • Yorihiro Yamamoto
  • ,
  • Misato Kashiba

710
開始ページ
108988
終了ページ
108988
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.abb.2021.108988
出版者・発行元
Elsevier BV

Monocytes are differentiated into macrophages. In this study, mitochondrial DNA copy number (mtDNAcn) levels and downstream events such as the expression of respiratory chain mRNAs were investigated during the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of monocytes. Although PMA treatment increased mtDNAcn, the expression levels of mRNAs encoded in mtDNA were decreased. The levels of mitochondrial transcription factor A mRNA and protein were also decreased. The levels of coenzyme Q10 remained unchanged. These results imply that, although mtDNAcn is considered as a health marker, the levels of mtDNAcn may not always be consistent with the parameters of mitochondrial functions.

リンク情報
DOI
https://doi.org/10.1016/j.abb.2021.108988
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34274337
ID情報
  • DOI : 10.1016/j.abb.2021.108988
  • ISSN : 0003-9861
  • PubMed ID : 34274337

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