論文

査読有り 本文へのリンクあり
2012年3月

LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites

Nature communications
  • Izumi Kawabata
  • ,
  • Yutaro Kashiwagi
  • ,
  • Kazuki Obashi
  • ,
  • Masamichi Ohkura
  • ,
  • Junichi Nakai
  • ,
  • Anthony Wynshaw-Boris
  • ,
  • Yuchio Yanagawa
  • ,
  • Shigeo Okabe

3
722
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ncomms1736
出版者・発行元
NATURE PUBLISHING GROUP

Synaptic remodelling coordinated with dendritic growth is essential for proper development of neural connections. After establishment of synaptic contacts, synaptic junctions are thought to become stationary and provide fixed anchoring points for further dendritic growth. However, the possibility of active translocation of synapses along dendritic protrusions, to guide the proper arrangement of synaptic distribution, has not yet been fully investigated. Here we show that immature dendrites of gamma-aminobutyric acid-positive interneurons form long protrusions and that these protrusions serve as conduits for retrograde translocation of synaptic contacts to the parental dendrites. This translocation process is dependent on microtubules and the activity of LIS1, an essential regulator of dynein-mediated motility. Suppression of this retrograde translocation results in disorganized synaptic patterns on interneuron dendrites. Taken together, these findings suggest the existence of an active microtubule-dependent mechanism for synaptic translocation that helps in the establishment of proper synaptic distribution on dendrites.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1038/ncomms1736
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000302630100011&DestApp=WOS_CPL

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