論文

査読有り 国際誌
2013年

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.

Nature communications
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回数 : 54
  • Euikyung Shin
  • ,
  • Yutaro Kashiwagi
  • ,
  • Toshihiko Kuriu
  • ,
  • Hirohide Iwasaki
  • ,
  • Teruyuki Tanaka
  • ,
  • Hiroyuki Koizumi
  • ,
  • Joseph G Gleeson
  • ,
  • Shigeo Okabe

4
1440
開始ページ
1440
終了ページ
1440
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ncomms2443

Dendritic morphogenesis and formation of synapses at appropriate dendritic locations are essential for the establishment of proper neuronal connectivity. Recent imaging studies provide evidence for stabilization of dynamic distal branches of dendrites by the addition of new synapses. However, molecules involved in both dendritic growth and suppression of synapse maturation remain to be identified. Here we report two distinct functions of doublecortin-like kinases, chimeric proteins containing both a microtubule-binding domain and a kinase domain in postmitotic neurons. First, doublecortin-like kinases localize to the distal dendrites and promote their growth by enhancing microtubule bundling. Second, doublecortin-like kinases suppress maturation of synapses through multiple pathways, including reduction of PSD-95 by the kinase domain and suppression of spine structural maturation by the microtubule-binding domain. Thus, doublecortin-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.

リンク情報
DOI
https://doi.org/10.1038/ncomms2443
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23385585
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017031

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