論文

国際誌
2019年8月

Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions.

Aging and disease
  • Takehiko Yamanaka
  • Yuto Uchida
  • Keita Sakurai
  • Daisuke Kato
  • Masayuki Mizuno
  • Toyohiro Sato
  • Yuta Madokoro
  • Yuko Kondo
  • Ayuko Suzuki
  • Yoshino Ueki
  • Fumiyasu Ishii
  • Cesar V Borlongan
  • Noriyuki Matsukawa
  • 全て表示

10
4
開始ページ
711
終了ページ
718
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.14336/AD.2018.0929

Although several studies have demonstrated correlation between white matter hyperintensities (WMH) and impairment of executive functions, the underlying anatomical-functional relationships are not fully understood. The present study sought to investigate the correlations between the volume of WMH and medial temporal lobe atrophy (MTA) using quantitative magnetic resonance image (MRI) and a variety of executive function assessments. A total of 91 patients ranging in age from 58 to 90 years with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) or early phase AD were recruited from the outpatient clinic at the Department of Neurology of Nagoya City University Hospital. We administered neuropsychological batteries evaluating verbal memory, orientation, spatial ability, sustained attention, and a variety of executive functions, including verbal fluency, flexibility, inhibition, and working memory. Quantitative MRI analyses were performed using Dr. View/Linux software and a voxel-based specific regional analysis system. Significant correlations were observed between WMH, as well as MTA, and some executive function scores. Regression analysis revealed that MTA was the strongest predictor of flexibility and verbal fluency. These findings provide new insight into the relationship between quantitative MRI analyses and various types of executive dysfunction in elderly people with MCI due to AD and/or early phase AD. When cognitive function is examined in elderly patients with MCI due to AD or early phase AD, it is important to consider the involvement of WMH and MTA, which is indicative of AD pathology in cognitive dysfunction, particularly executive function.

リンク情報
DOI
https://doi.org/10.14336/AD.2018.0929
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31440378
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675535
ID情報
  • DOI : 10.14336/AD.2018.0929
  • PubMed ID : 31440378
  • PubMed Central 記事ID : PMC6675535

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