2008年6月
Relationship between oral health status and development of osteoradionecrosis of the mandible: a retrospective longitudinal study.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
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- 巻
- 105
- 号
- 6
- 開始ページ
- 731
- 終了ページ
- 8
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tripleo.2007.10.011
- 出版者・発行元
- MOSBY-ELSEVIER
OBJECTIVE: Oral health status is a risk factor for postradiation bone complications (also known as osteoradionecrosis [ORN]), and oral health care is an important element in the prevention of this condition. Some authors recommend extracting teeth with a questionable prognosis and either gross mobility or periodontal disease. However, the criteria for making such decisions remain to be elucidated. In addition, the specific details of the association between oral health status and ORN have not yet been clearly demonstrated. The purpose of this study was to clarify the relationship between oral health status and the development of ORN. STUDY DESIGN: Thirty-nine head and neck cancer patients whose radiation fields included both the teeth and the mandible were followed for > or = 3 years after radiotherapy. Among these patients, 6 suffered from ORN (ORN group), and the other 33 did not experience the condition (non-ORN group). We analyzed the patient factors, radiation factors, and oral health factors related to the complication. RESULTS: The onset of ORN occurred from 18 months to 51 months after radiotherapy. The radiation dose in the oral cavity and the oral health status before radiotherapy were not significant risk factors for ORN. However, the oral health status at 1 year or 2 years after radiotherapy was significantly associated with the development of ORN. The oral health conditions that increased the risk of ORN were > 5 mm periodontal pocket depth, > 40% dental plaque score, > 60% alveolar bone loss level, and a grade 3 radiographic periodontal status. CONCLUSION: This is the first report to show the changes in the oral health status before and after radiotherapy regarding the development of ORN. The results support the periodontal status that almost all clinicians agree on as indications for preradiation teeth extraction (namely, periodontal pockets of > 5 mm) to prevent ORN. Good oral health status, especially after radiotherapy, is very important in the prevention of ORN, and we recommend periodical dental management and care by well trained dentists and dental hygienists to avoid the condition.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.tripleo.2007.10.011
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18329913
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000256261800010&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- 癌・放射線治療による晩期有害事象のリスクファクターの特定と予防管理システムの考察
- ID情報
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- DOI : 10.1016/j.tripleo.2007.10.011
- ISSN : 1079-2104
- eISSN : 1528-395X
- PubMed ID : 18329913
- Web of Science ID : WOS:000256261800010