Isotopic compositions of Sr, Nd and Pb and REE concentrations have been determined for samples from ''isotopically anomalous'' Akagi volcano locating on the Volcanic front of Northeast Japan Are. The Sr isotopic compositions show a large variation with highly enriched isotope character (Sr-87/Sr-86=0.7060 to 0.7088) compared to those from other volcanoes on the front. The Nd isotopic compositions, ranging from epsilon(Nd) = -0.40 to -8.6, have a negative correlation with the Sr isotopic compositions. The Pb isotopic data along with Sr and Nd isotope systematics clearly indicate that the isotopic variations of Akagi volcano were caused by a two-component mixing between an end member isotopically similar to the primary magma on the volcanic front of Northeast Japan Are and a lower crustal component. Chondrite-normalized REE patterns of Akagi samples show U-shaped, HREE-depleted pattern with positive Eu anomaly. Such REE features may have been developed by fractionation of amphibole formed by the reaction between a fluid-rich magma and clinopyroxene in granulitic lower crust. The fluid-rich magma could be originated from a highly metasomatized mantle wedge caused by the dehydration of oceanic slabs of the Pacific plate and the overlapping Philippine Sea Plate. Such a unique tectonic setting could result in higher water supply to the source region of magma than normal circumstances and thereby generating fluid-rich magma which could enhance assimilation of lower crust beneath Akagi volcano.