2019年
内側前頭前野内レゾルビンE1投与はBDNFとVEGFの遊離およびmTORC1活性化を介してリポポリサッカライド誘発うつ病様行動を減弱する
日本薬理学会年会要旨集
- ,
- ,
- ,
- ,
- ,
- 巻
- 92
- 号
- 0
- 開始ページ
- 2
- 終了ページ
- P-029
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.1254/jpssuppl.92.0_2-P-029
- 出版者・発行元
- 公益社団法人 日本薬理学会
<p>We have recently demonstrated that infusion of eicosapentaenoic acid-derived resolvin E1 (RvE1; 50 pg/side) into the medial prefrontal cortex (mPFC) exerts antidepressant effect in a murine lipopolysaccharide (LPS)-induced depression model. In the present study, we examined the roles of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and their downstream mTORC1 in the antidepressant actions of intra-mPFC RvE1 infusion in LPS-induced depression model mice using the tail suspension and forced swim tests. The results demonstrate that the antidepressant effects of intra-mPFC RvE1 infusion are completely blocked by co-infusion of a BDNF neutralizing antibody (nAb), a VEGF nAb or an mTORC1 inhibitor rapamycin. We also demonstrate that the antidepressant effects of intra-mPFC BDNF or VEGF infusion are blocked by co-infusion of rapamycin. Together, the current results indicate that BDNF/VEGF release and subsequent activation of mTORC1 in the mPFC are required for the antidepressant actions of RvE1.</p>
- リンク情報
- ID情報
-
- DOI : 10.1254/jpssuppl.92.0_2-P-029
- CiNii Articles ID : 130007812998