論文

査読有り
2017年1月

Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma

ONCOTARGET
  • Kan Tanabe
  • Yoshinari Shinsato
  • Tatsuhiko Furukawa
  • Yoshiaki Kita
  • Kazuhito Hatanaka
  • Kentaro Minami
  • Kohichi Kawahara
  • Masatatsu Yamamoto
  • Kenji Baba
  • Shinichiro Mori
  • Yasuto Uchikado
  • Kosei Maemura
  • Akihide Tanimoto
  • Shoji Natsugoe
  • 全て表示

8
4
開始ページ
6353
終了ページ
6363
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18632/oncotarget.14087
出版者・発行元
IMPACT JOURNALS LLC

To establish treatments to improve the prognosis of cancer patients, it is necessary to find new targets to control metastasis. We found that expression of FilaminC ( FLNC), a member of the actin binding and cross-linking filamin protein family is correlated with lymphatic invasion and lymphatic metastasis in esophageal squamous cell carcinoma (ESCC) by increasing cell motility through activation of Rho GTPase.
Immunohistochemistry analysis showed that FLNC expression in ESCC is associated with lymphatic invasion, metastasis, and prognosis. FLNC knockdown in esophageal cancer cell lines decreased cell migration in wound healing and transwell migration assays, and invasion in transwell migration assays. Furthermore, FLNC knockdown reduced the amount of activated Rac-1 (GTP-Rac1) and activated Cdc42 (GTP-Cdc42). Our results suggest that FLNC expression is a useful biomarker of ESCC metastatic tendency and that inhibiting FLNC function may be useful to control the metastasis of ESCC.

リンク情報
DOI
https://doi.org/10.18632/oncotarget.14087
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393289000080&DestApp=WOS_CPL
ID情報
  • DOI : 10.18632/oncotarget.14087
  • ISSN : 1949-2553
  • Web of Science ID : WOS:000393289000080

エクスポート
BibTeX RIS