2016年8月
Discovery of a new function of curcumin which enhances its anticancer therapeutic potency
SCIENTIFIC REPORTS
- ,
- ,
- ,
- ,
- ,
- 巻
- 6
- 号
- 開始ページ
- 30962
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep30962
- 出版者・発行元
- NATURE PUBLISHING GROUP
Curcumin has received immense attention over the past decades because of its diverse biological activities and recognized as a promising drug candidate in a large number of diseases. However, its clinical application has been hindered due to extremely low aqueous solubility, chemical stability, and cellular uptake. In this study, we discovered quite a new function of curcumin, i.e. pH-responsive endosomal disrupting activity, derived from curcumin's self-assembly. We selected anticancer activity as an example of biological activities of curcumin, and investigated the contribution of pH-responsive property to its anticancer activity. As a result, we demonstrated that the pH-responsive property significantly enhances the anticancer activity of curcumin. Furthermore, we demonstrated a utility of the pH-responsive property of curcumin as delivery nanocarriers for doxorubicin toward combination cancer therapy. These results clearly indicate that the smart curcumin assemblies act as promising nanoplatform for development of curcumin-based therapeutics.
- リンク情報
- ID情報
-
- DOI : 10.1038/srep30962
- ISSN : 2045-2322
- Web of Science ID : WOS:000381060100001