2020年12月
New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression
Current Opinion in Immunology
- ,
- ,
- 巻
- 67
- 号
- 開始ページ
- 36
- 終了ページ
- 41
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.coi.2020.07.004
- 出版者・発行元
- Elsevier BV
Naturally occurring FoxP3+CD4+ regulatory T (Treg) cells indispensable for the maintenance of immunological self-tolerance and homeostasis are instrumental in treating autoimmune and other immunological disorders. Stable function of natural Treg cells requires not only the expression of Foxp3 and other Treg signature genes such as CD25 and CTLA-4 but also the generation of Treg-specific epigenetic changes, especially Treg-specific DNA hypomethylation, at these gene loci. Recent studies have shown that the Treg-specific transcriptional and epigenetic changes can be induced in antigen-specific conventional T cells in vivo and in vitro, converting them to functionally stable Treg cells. Such natural or induced Treg cells bear the potential to achieve stable antigen-specific immune suppression and reestablish immunological self-tolerance in treating and preventing autoimmune diseases.
- リンク情報
- ID情報
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- DOI : 10.1016/j.coi.2020.07.004
- ISSN : 0952-7915
- PubMed ID : 32827951