論文

2023年

Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence.

Chemical & pharmaceutical bulletin
  • Sayuri Kawamoto
  • Shimako Tanaka
  • Motoyasu Miura
  • Yasuharu Kashiwagura
  • Chiaki Kamiya
  • Akio Hakamata
  • Keiichi Odagiri
  • Naoki Inui
  • Hiroshi Watanabe
  • Noriyuki Namiki
  • Shinya Uchida
  • 全て表示

71
6
開始ページ
441
終了ページ
446
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/cpb.c23-00102

Good adherence to medication is critical for successfully treating psychiatric disorders. Tailor-made pharmaceutical formulations can provide a suitable dosage form to meet the specific needs of individual patients who exhibit poor adherence to industrially manufactured products. Herein, we prepared aripiprazole (ARP) gummies (ARP-Gs) using a commercially available ARP formulation. We aimed to clarify the palatability of ARP-Gs by performing a gustatory sensation test in healthy volunteers. We performed two types of organoleptic masking of ARP-Gs, cocoa- and fruit-flavoured gummies (6.0 mg of ARP/3.5 g of gummy), and conducted two different gustatory sensation tests for each ARP-G. Ten young, healthy volunteers (mean ± standard deviation, 23.7 ± 1.2 years) were enrolled in each trial. The overall palatability of ARP-Gs was evaluated using the 100-mm visual analogue scale (VAS). Receiver operating characteristic (ROC) curve analysis was performed between VAS scores of total ARP-G palatability and acceptability assessed using a 5-point rating scale. Among cocoa-flavoured ARP-Gs, those combining aspartame, cocoa powder, and banana flavour (ABC-ARP-G) exhibited the highest VAS scores for total palatability. Similarly, the VAS scores of grapefruit-flavoured ARP-Gs (GF-ARP-G) showed the highest values considering all fruit-flavoured ARP-Gs. The VAS scores for ABC-ARP-G and GF-ARP-G greatly exceeded the cut-off values of acceptability calculated using the ROC curve. We developed two types of ARP-Gs with organoleptic masking as tailor-made pharmaceutical formulations. ABC-ARP-Gs and GF-ARP-Gs could be acceptable in patients. ARP-Gs could be an alternative to currently available pharmaceutical formulations to enhance their adherence and meet the specific needs of individual patients.

リンク情報
DOI
https://doi.org/10.1248/cpb.c23-00102
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/37258198
ID情報
  • DOI : 10.1248/cpb.c23-00102
  • PubMed ID : 37258198

エクスポート
BibTeX RIS