MISC

2010年7月

Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues

Obesity
  • Satoshi Ugi
  • ,
  • Yoshihiko Nishio
  • ,
  • Hiroshi Yamamoto
  • ,
  • Kazuhiro Ikeda
  • ,
  • Masaaki Kobayashi
  • ,
  • Shuichi Tsukada
  • ,
  • Motoyuki Kondo
  • ,
  • Katsutaro Morino
  • ,
  • Toshiyuki Obata
  • ,
  • Takeshi Yoshizaki
  • ,
  • Takashi Uzu
  • ,
  • Hiroyuki Naitoh
  • ,
  • Toru Tani
  • ,
  • Shiro Maeda
  • ,
  • Atsunori Kashiwagi
  • ,
  • Hiroshi Maegawa

18
7
開始ページ
1277
終了ページ
1282
記述言語
英語
掲載種別
DOI
10.1038/oby.2009.442

To determine the potential role of the transcriptional factor-activating enhancer-binding protein-2Β (TFAP2B) in the regulation of expression of adipokines, adiponectin, leptin, and interleukin-6 (IL-6) in vivo, we quantified the mRNA expression levels of these adipokines and TFAP2B in visceral (omental) and abdominal subcutaneous adipose tissues of 66 individuals with variable degree of adiposity and studied their correlations with BMI and their plasma concentrations. We found that BMI correlated negatively with plasma adiponectin levels and positively with those of leptin. Adiponection mRNA expression in subcutaneous fat correlated negatively with BMI, whereas leptin mRNA levels in the omentum correlated with plasma leptin levels and BMI. In contrast, IL-6 mRNA levels in subcutaneous and omental fat did not correlate with BMI. IL-6 mRNA levels in the omental fat correlated with plasma IL-6 levels. Whereas TFAP2B mRNA expression did not correlate with BMI, it correlated negatively with adiponectin expression in the subcutaneous adipose tissue. Furthermore, TFAP2B mRNA expression correlated negatively with leptin and positively with IL-6 expression in both subcutaneous and omental adipose tissues. These relationships are consistent with our in vitro observations and indicate that TFAP2B seems to regulate the expression of various adipokines in vivo. © 2009 The Obesity Society.

リンク情報
DOI
https://doi.org/10.1038/oby.2009.442
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20019683

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