論文

査読有り
2013年

Octreotide improves early dumping syndrome potentially through incretins: A case report

Endocrine Journal
  • Daisuke Sato
  • ,
  • Katsutaro Morino
  • ,
  • Natsuko Ohashi
  • ,
  • Emi Ueda
  • ,
  • Kazuhiro Ikeda
  • ,
  • Hideka Yamamoto
  • ,
  • Satoshi Ugi
  • ,
  • Hiroshi Yamamoto
  • ,
  • Shinichi Araki
  • ,
  • Hiroshi Maegawa

60
7
開始ページ
847
終了ページ
853
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1507/endocrj.EJ12-0288
出版者・発行元
7

Dumping syndrome, or rapid gastric emptying, is a frequent complication after gastric surgery. In this case, the patient was a 47-year-old woman who 10 years previously had undergone distal gastrectomy with Billroth I reconstruction for early-stage gastric cancer. She presented with symptoms of weakness, headache, palpitation, sweating, dizziness and significant fatigue between one and two hours after a meal. Because a 75g oral glucose tolerance test (75g-OGTT) induced both acute postprandial tachycardia (within 1 hour) and postprandial hypoglycemia, we diagnosed this patient with early and late dumping syndrome. Dietary measures and acarbose improved symptoms of late dumping syndrome but did not prevent the symptoms of early dumping syndrome such as postprandial tachycardia, weakness, headache, palpitation, and dizziness. We therefore used the somatostatin analogue octreotide, which has been reported as an effective therapy for early dumping syndrome. Octreotide prevented the symptoms of early dumping syndrome, especially postprandial tachycardia, but caused postprandial hyperglycemia. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were completely suppressed during the 75g-OGTT following subcutaneous injection of octreotide. No change was observed in vasoactive intestinal polypeptide (VIP), which is the gastrointestinal peptide hormone generally responsible for early dumping syndrome, suggesting possible contribution of incretins in early dumping syndrome of this patient. © The Japan Endocrine Society.

リンク情報
DOI
https://doi.org/10.1507/endocrj.EJ12-0288
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23708181

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