Kazuhiro Shigemoto

Profile Information

J-GLOBAL ID: 202001021386580239
researchmap Member ID: R000009575

Research Interests

Sarcopenia, Frailty, muscle atrophy, neuromuscular disease, neuromuscular junction, metabolic shift

Papers

神経筋シナプスの機能不全を診断する新しいバイオマーカーの開発

重本和宏, 森秀一, 周赫英, 大村卓也, 津元裕樹, 三浦ゆり

基礎老化研究, 47(2) 77-77, Jun, 2023
筋線維タイプ変化と筋代謝特性変換のin vitro解析系の構築

河野真子, 大村卓也, 森秀一, 栗原佐知子, 古関明彦, 重本和宏

基礎老化研究, 47(2) 79-79, Jun, 2023
Sympathetic modulation of hindlimb muscle contractility is altered in aged rats.

Harumi Hotta, Kaori Iimura, Nobuhiro Watanabe, Harue Suzuki, Masamitsu Sugie, Kazuhiro Shigemoto

Scientific reports, 13(1) 7504-7504, May 16, 2023
Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis.

Shuuichi Mori, Shigeaki Suzuki, Tetsuro Konishi, Naoki Kawaguchi, Masahiko Kishi, Satoshi Kuwabara, Kei Ishizuchi, Heying Zhou, Futoshi Shibasaki, Hiroki Tsumoto …

Experimental neurology, 361 114300-114300, Dec 13, 2022
サルコペニア基礎研究の最前線ミトコンドリア形態と機能に着目したサルコペニアの発症メカニズム

重本和宏, 福永大地, 大村卓也, 岸田広美

日本老年医学会雑誌, 59(Suppl.) 29-29, May, 2022
サルコペニア基礎研究の最前線ミトコンドリア形態と機能に着目したサルコペニアの発症メカニズム

重本和宏, 福永大地, 大村卓也, 岸田広美

日本老年医学会雑誌, 59(Suppl.) 29-29, May, 2022
「核とミトコンドリア研究」から視えてきた疾患病態の先端生化学加齢マウスにおける筋線維タイプ別のミトコンドリア呼吸機能および形態の変化

重本和宏, 福永大地, 森秀一, 大村卓也, 野田義博, 藤田泰典, 大澤郁朗

日本生化学会大会プログラム・講演要旨集, 94回 [1S05m-01], Nov, 2021
Maintenance of contractile force of the hind limb muscles by the somato-lumbar sympathetic reflexes.

Harumi Hotta, Kaori Iimura, Nobuhiro Watanabe, Kazuhiro Shigemoto

The journal of physiological sciences : JPS, 71(1) 15-15, May 21, 2021 Peer-reviewedLast author
【フレイル予防・対策:基礎研究から臨床、そして地域へ】基礎研究からの最新知見メカニズムから解き明かすサルコペニアの病態

大村卓也, 重本和宏

Advances in Aging and Health Research, 2020 177-190, Mar, 2021
Muscle fiber type specific alterations of mitochondrial respiratory function and morphology in aged female mice.

Taichi Fukunaga, Shuuichi Mori, Takuya Omura, Yoshihiro Noda, Yasunori Fujita, Ikuroh Ohsawa, Kazuhiro Shigemoto

Biochemical and biophysical research communications, 540 116-122, Feb 12, 2021 InvitedLast authorCorresponding author
サルコ・フレイルの基礎研究徹底討論サルコペニア・フレイルのメカニズムと運動および食事との関連性とは?

重本和宏, 大村卓也, 岸田広美

日本サルコペニア・フレイル学会雑誌, 4(Suppl.) 41-41, Nov, 2020
Geriatric practice during and after the COVID-19 pandemic.

Takuya Omura, Atsushi Araki, Kazuhiro Shigemoto, Kenji Toba

Geriatrics & gerontology international, 20(7) 735-737, Jul, 2020 Invited
サルコペニア・フレイルのメカニズムの解明に向けて

重本和宏, 大村卓也, 岸田広美, 森秀一

日本臨床栄養学会雑誌, 41(4) 246-255, Jun, 2020
【サルコペニア診断と治療Update】サルコペニアのバイオマーカー探索

重本和宏, 大村卓也

Medical Practice, 37(5) 745-747, May, 2020
Meningoencephalitis caused by masked mastoiditis that was diagnosed during a follow-up in an elderly patient with diabetes mellitus: A case report.

Takuya Omura, Rie Motoyama, Yoshiaki Tamura, Keisuke Nonaka, Zen-Ichi Tanei, Kazuhiro Shigemoto, Aya Midori Tokumaru, Shigeo Murayama, Tomio Arai, Atsushi Araki

Geriatrics & gerontology international, 20(5) 500-501, May, 2020 Invited
Oldest-old type 1 diabetes patient receiving insulin pump treatment with positive myeloperoxidase-antineutrophil cytoplasmic antibody complication: A case report.

Takuya Omura, Yoshiaki Tamura, Remi Kodera, Kazuhito Oba, Kenji Toyoshima, Yuko Chiba, Takahiro Sugihara, Mitsuyo Itabashi, Kazuhiro Shigemoto, Atsushi Araki

Geriatrics & gerontology international, 19(9) 957-958, Sep, 2019 Peer-reviewed
Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.

T Miyazaki, Z Zhao, Y Ichihara, D Yoshino, T Imamura, K Sawada, S Hayano, H Kamioka, S Mori, H Hirata …

Science advances, 5(9) eaau7802, Sep, 2019 Peer-reviewed
Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle.

Norio Motohashi, Akiyoshi Uezumi, Atsushi Asakura, Madoka Ikemoto-Uezumi, Shuuichi Mori, Yuhei Mizunoe, Rumi Takashima, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Kazuhiro Shigemoto

Cell death and differentiation, 26(6) 1024-1036, Jun, 2019 Peer-reviewedLast author
Practical Anatomy of the Neuromuscular Junction in Health and Disease.

Hiroshi Nishimune, Kazuhiro Shigemoto

Neurologic clinics, 36(2) 231-240, May, 2018 Peer-reviewedInvitedLead authorLast authorCorresponding author
Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis.

Shuuichi Mori, Norio Motohashi, Rumi Takashima, Masahiko Kishi, Hiroshi Nishimune, Kazuhiro Shigemoto

Experimental neurology, 297 158-167, Nov, 2017 Peer-reviewedLast authorCorresponding author

Misc.

Age-related mitochondrial alterations in skeletal muscle depend on muscle fiber type units

大村卓也, 福永大地, 森秀一, 河野真子, 野田義博, 藤田泰典, 大澤郁朗, 重本和宏

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
The role of mitochondria in sarcocenia

重本和宏, 福永大地, 大村卓也

医学のあゆみ, 279(5), 2021
高齢者の運動を考える 2.骨格筋の代謝からみた運動

重本和宏, 福永大地, 大村卓也

Geriatric Medicine, 59(10), 2021
加齢マウスにおける筋線維タイプ別のミトコンドリア呼吸機能および形態の変化

重本和宏, 福永大地, 森秀一, 大村卓也, 野田義博, 藤田泰典, 大澤郁朗

日本生化学会大会(Web), 94th [1S05m-01], 2021
老化研究の進歩(Vol.15) フレイルの病態メカニズム

重本和宏, 大村卓也, 森秀一

医学のあゆみ, 274(2) 225-230, Jul, 2020
実験動物施設への二酸化塩素ガス滅菌法の導入と運用

野田義博, 根本妙子, 安西尚子, 安西尚子, 土田学, 土田学, 重本和宏

実験動物と環境, (55), 2020
自然老化マウスの加齢性筋萎縮に伴う運動機能の評価

野田義博, 根本妙子, 大村卓也, 大石奈都美, 重本和宏

日本実験動物技術者協会総会講演要旨集, 53rd, 2019
自然加齢による老化動物の育成

野田義博, 根本妙子, 安西尚子, 高橋洋子, 重本和宏, 遠藤玉夫

日本実験動物技術者協会総会講演要旨集, 52nd, 2018
筋線維タイプを識別できるMusColorマウスの開発

本橋紀夫, 森秀一, 高嶋留美, 重本和宏

日本筋学会学術集会プログラム・抄録集, 4th, 2018
骨格筋代謝制御因子の同定

本橋紀夫, 朝倉淳, 森秀一, 高嶋留美, 上住円, 上住聡芳, 重本和宏

日本筋学会学術集会プログラム・抄録集, 3rd, 2017
SUPER RESOLUTION MICROSCOPY ANALYSIS OF NMJ ACTIVE ZONES IN ADULT AND AGED MICE

H. Nishimune, S. Mori, Y. Badawi, K. Shigemoto

MUSCLE & NERVE, 52 S137-S137, Oct, 2015
骨格筋幹細胞における維持機構の解明

本橋紀夫, 朝倉淳, 森秀一, 高嶋留美, 重本和宏

基礎老化研究, 39(2), 2015
Involvement of the nervous system in sarcopenia onset

248(9) 691-695, Mar 1, 2014
Maintenance of neuromuscular junction and muscle atrophy

244(8) 696-703, Feb 23, 2013
Skeletal muscle and motor neuron : underlying mechanisms in sarcopenia

Bone joint nerve : BJN, 3(1) 27-31, Jan, 2013
MuSK抗体陽性重症筋無力症の受動免疫モデルの重要性について

岸雅彦, 森秀一, 久保幸穂, 榊原隆次, 舘野冬樹, 露崎洋平, 太田潔江, 重本和宏

臨床神経学, 52(12) 1621-1621, Dec, 2012 Peer-reviewed
老齢マウスの筋線維タイプ特異的な筋萎縮の病態解明

福永大地, 久保幸穂, 森秀一, 宮崎剛, 樋上賀一, 重本和宏

基礎老化研究, 36(3) 47-49, Sep 27, 2012
Maintenance of mitochondrial DNA copy number is essential for osteoclast survival

Tsuyoshi Miyazaki, Shuuichi Mori, Kazuhiro Shigemoto, Nils-Goran Larsson, Takeshi Nakamura, Shigekaki Kato, Tomoki Nakashima, Hiroshi Takayanagi, Sakae Tanaka

ARTHRITIS RESEARCH & THERAPY, 14, 2012
Pathogenic mechanisms of myasthenia gravis induced by antibodies against muscle-specific kinase

MARUYAMA Naoki, SHIGEMOTO Kazuhiro

Clinical neurology., 47(11) 842-844, Nov 1, 2007
筋細胞におけるアセチルコリン受容体凝集の解析と応用

久保幸穂, 重本和宏, 石神昭人, 半田節子, 丸山直記

東京都老年学会誌, 11th, 2005

Professional Memberships

Research Projects

嚥下にともなう自律神経の活性化が骨格筋におよぼす作用とサルコペニア予防への応用

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2025

堀田晴美, 重本和宏
Elucidation of pathogenesis of sarcopenia based on the plasticity of metabolism of skeletal muscle

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Shigemoto Kazuhiro
Elucidation of pathogenesis of sarcopenia based on the mechanism of metabolic changes of skeletal muscle

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Shigemoto Kazuhiro
Blood concentration of postsynaptic membrane protein A reflects physical performance in aged people

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Zhou Heying, Shigemoto Kazuhiro, Shinkai shoji
Molecular pathological analysis of presbycusis ~focused on cochlear lateral wall~

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Kimura Yurika, KITAMURA KEN, IKEZONO TETSURO, SHIGEMOTO KAZUHIRO, SAWABE MOTOJI, KUBO SACHIHO, KOBAYASHI HITOME
Elucidation of metabolic shift of skeletal muscle during aging and invention of new therapies for sarcopenia

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

SHIGEMOTO Kazuhiro
Elucidation of pathogenic mechanisms and developing new therapies of myasthenia gravis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SHIGEMOTO KAZUHIRO, MORI Shuuichi, EDAMATSU Midori, MIYAZAKI Tsuyoshi, KOSHI Katsuo, KONISHI Tetsuro
Elucidation of the molecular mechanisms of muscle atrophy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project), Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project), Japan Society for the Promotion of Science, 2009 - 2011

SHIGEMOTO Kazuhiro, KUBO Sachiho, MIYAZAKI Tsuyoshi, YAMADA Shigeru
Elucidation of pathogenic mechanisms of myasthenia gravis caused by MuSK antibodies using a new synchronized experimental animal model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

SHIGEMOTO Kazuhiro, KONISHI Tetsuro
Analysis of pathogenic roles of MuSK antibodies in myasthenia gravis using the experimental animal models.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

SHIGEMOTO Kazuhiro, UEDA Norifumi, MATSUDA Seiji
Analysis of myasthenic disease caused by MuSK dysfunction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

SHIGEMOTO Kazuhiro, MOMINOKI Katsumi, MATSUDA Seiji, MARUYAMA Naoki, KUBO Sachiho
Analysis of MuSK functions and the molecular pathogenesis of myasthenia gravis with anti-MuSK autoantibodies by proteomic approaches

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

SHIGEMOTO Kazuhiro, MARUYAM Naoki
パーキンソン病の環境的並びに遺伝的因子の解明

科学研究費助成事業重点領域研究, 重点領域研究, 日本学術振興会, 1997 - 1997

近藤郁子, 重本和宏
The analysis of B cell differentiation and maturation

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B), Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1990 - 1991

TAKEMORI Toshitada, TOKUHISA Takeshi, MIZUGUCHI Junichiro, OHNISHI Kazuo, KIMOTO Hiroshi
胎児胸腺由来幼若造血細胞株の確立とその多能性分化能の解析

科学研究費助成事業重点領域研究, 重点領域研究, 日本学術振興会, 1990 - 1990

竹森利忠, 谷山忠義, 大西和夫, 重本和宏
Analysis of lymphoid cell differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B), Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1988 - 1989

TAKEMORI Toshitada, SHIGEMOTO Kazuhiro, TAGAWA Masatoshi
温度感受性レトロウイルスを用いたリンパ球の腫瘍発症と分化抑制機構の解析

科学研究費助成事業がん特別研究, がん特別研究, 日本学術振興会, 1988 - 1988

竹森利忠, 重本和宏
未分化細胞で発現可能なレトロウィルスベクターの開発と骨髄リンパ球幹細胞株の樹立

科学研究費助成事業奨励研究(A), 奨励研究(A), 日本学術振興会, 1987 - 1987

重本和宏

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