2017年2月
Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication
CELL METABOLISM
- ,
- ,
- ,
- 巻
- 25
- 号
- 2
- 開始ページ
- 322
- 終了ページ
- 334
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cmet.2016.12.002
- 出版者・発行元
- CELL PRESS
Hypothalamic neuropeptide Y (NPY) elicits hunger responses to increase the chances of surviving starvation: an inhibition of metabolism and an increase in feeding. Here we elucidate a key central circuit mechanism through which hypothalamic NPY signals drive these hunger responses. GABAergic neurons in the intermediate and parvicellular reticular nuclei (IRt/PCRt) of the medulla oblongata, which are activated by NPY-triggered neural signaling from the hypothalamus, potentially through the nucleus tractus solitarius, mediate the NPY-induced inhibition of metabolic thermogenesis in brown adipose tissue (BAT) via their innervation of BAT sympathetic premotor neurons. Intriguingly, the GABAergic IRt/PCRt neurons innervating the BAT sympathetic premotor region also innervate the masticatory motor region, and stimulation of the IRt/PCRt elicits mastication and increases feeding as well as inhibits BAT thermogenesis. These results indicate that GABAergic IRt/PCRt neurons mediate hypothalamus-derived hunger signaling by coordinating both autonomic and feeding motor systems to reduce energy expenditure and to promote feeding.
- リンク情報
- ID情報
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- DOI : 10.1016/j.cmet.2016.12.002
- ISSN : 1550-4131
- eISSN : 1932-7420
- Web of Science ID : WOS:000396354400014