山本和博 (Kazuhiro Yamamoto) - マイポータル

基本情報

所属: 東京農工大学農学部附属硬蛋白質利用研究施設准教授

研究者番号: 50448685
ORCID iD: https://orcid.org/0000-0002-8481-775X
J-GLOBAL ID: 202501008132585931
researchmap会員ID: R000083670

研究キーワード

研究分野

経歴

2025年3月 - 現在

東京農工大学, 農学部附属硬蛋白質利用研究施設, 准教授
2025年3月 - 現在

University of Liverpool, Institute of Life Course and Medical Sciences, Honorary Lecturer
2023年4月 - 現在

University of Liverpool, Institute of Life Course and Medical Sciences, Versus Arthritis Bridging Fellow
2023年1月 - 2025年2月

University of Liverpool, Institute of Life Course and Medical Sciences, Lecturer
2019年1月 - 2023年1月

University of Liverpool, Institute of Life Course and Medical Sciences, Tenure Track Lecturer
2017年6月 - 2022年9月

University of Liverpool, Institute of Life Course and Medical Sciences, Versus Arthritis Career Development Fellow
2014年2月 - 2017年6月

University of Oxford, Kennedy Institute of Rheumatology, Arthritis Research UK Research Fellow
2011年7月 - 2014年1月

University of Oxford, Kennedy Institute of Rheumatology, Postdoctoral Research Associate
2008年12月 - 2011年7月

Imperial College London, Kennedy Institute of Rheumatology, Postdoctoral Research Associate
2006年4月 - 2008年11月

横浜市立大学, 木原生物学研究所, ポスドク研究員

学歴

2002年4月 - 2006年3月

横浜市立大学木原生物学研究所, 総合理学研究科, 博士後期課程
2000年4月 - 2002年3月

横浜市立大学木原生物学研究所, 総合理学研究科, 博士前期課程
1995年4月 - 2000年3月

横浜市立大学, 国際総合科学部（旧横浜市立大学理学部）
1992年4月 - 1995年3月

千葉県立柏高等学校

委員歴

2023年 - 現在

Dunhill Medical Trust, Academy member
2020年 - 2024年

University of Liverpool, Module Review Board/ Board of Studies for MRes Clinical Sciences
2020年 - 2024年

University of Liverpool, Research Ethics Committee Member
2014年 - 2017年

University of Oxford, Member of Congregation

受賞

2023年3月

Exceptional Performance Award, University of Liverpool
2019年3月

Award of Additional Increments, University of Liverpool
2015年7月

海外若手研究者招聘企画旅費補助, 日本生化学会・日本分子生物学会
2011年8月

Outstanding Research Poster Award, The 2011 Gordon Research Conference on Matrix Metalloproteinases
2010年2月

Best Scientific Presentation Award- 2nd place, The 27th Winter School on Proteinases and Their Inhibitors

論文

Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease

Rens de Groot, Patricia Badía Folgado, Kazuhiro Yamamoto, Daniel R. Martin, Christopher D. Koch, Danielle Debruin, Sophie Blagg, Alexander F. Minns, Sumit Bhutada, Josefin Ahnström …

Matrix Biology 135 106-124 2025年2月
Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight.

Jensen, A., Clarke, EJ, Nugent, Z., Paice, E., Gringel, I., Yamamoto, K., Rocchigiani, G., Peffers, AJ, Cooper, L., Peffers, MJ

Equine Veterinary Journal 2025年1月8日
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation.

Alhashmi, M., Gremida, AME, Maharana, SK, Antonaci, M., Kerr, A., Fu, S., Lunn, S., Turner, DA, Al-Maslamani, NA, Liu, K. …

Bone Research 13(1) 17-17 2025年1月
Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.

Yamamoto, K., Scilabra, SD, Bonelli, S., Jensen, A., Scavenius, C., Enghild, JJ, Strickland, DK

Journal of Biological Chemistry 300(8) 107521-107521 2024年8月
The low-density lipoprotein receptor-related protein 1 regulates non-canonical Wnt signalling and its deficiency causes severe and multiple skeletal defects.

Gremida, A., Wheeler, G., Yamamoto, K., Bou-Gharios, G., Clegg, P., Hof, RVT, Alhashmi, M., Noor, A-M., Antonaci, M., Maharana, S.

Osteoarthritis and Cartilage 32(6) 812-812 2024年6月
Tissue- and context-dependent roles of the low-density lipoprotein receptor-related protein 1 in mouse models of osteoarthritis

Yamamoto, K., Gremida, A., Milner, P., Kobayashi, Y., Nagase, H., Hof, RVT, Bou-Gharios, G.

Osteoarthritis and Cartilage 32(6) 811-811 2024年6月
Bioengineering of transcriptional elements driving MMP13 gene in skeletal development.

AlSalhi, SI

2024年5月24日
Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractile-strain-driven collagen degradation

Saini, K., Cho, S., Tewari, M., Jalil, A., Wang, M., Kasznel, A., Yamamoto, K., Chenoweth, DM, Discher, DE

Biophysical Journal 123(3) 469a-469a 2024年2月
Expression and Purification of Active Monomeric MMP7

Yamamoto, K., Isohata, M., Higashi, S.

Methods in molecular biology (Clifton, N.J.) 2747 67-73 2024年
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth

Mohammad Alhashmi, Abdulrahman ME Gremida, Noor A Al-Maslamani, Ke Liu, Hazel Sutherland, Peter Wilson, Peter Clegg, Robert J van ’t Hof, George Bou-Gharios, Kazuhiro Yamamoto

2023年7月12日
The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity

Minns, A.F., Qi, Y., Yamamoto, K., Lee, K., Ahnstr{\"o}m, J., Santamaria, S.

Journal of Biological Chemistry 299(4) 2023年
Editorial: ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the -Omics era-Volume II

Kwok, H.F., Yamamoto, K., de Groot, R., Scilabra, S.D., Santamaria, S.

Frontiers in Molecular Biosciences 10(ARTN 1172288) 2023年
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations

Noor A. Al-Maslamani, Rachel Oldershaw, Simon Tew, Jude Curran, Pieter D’Hooghe, Kazuhiro Yamamoto, Henning Horn

Cells 2022年12月
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage

Kazuhiro Yamamoto, Carsten Scavenius, Maria M Meschis, Abdulrahman M E Gremida, Emilie H Mogensen, Ida B Thøgersen, Simone Bonelli, Simone D Scilabra, Anders Jensen, Salvatore Santamaria …

Matrix Biology S0945-053X(22)00101-9-S0945-053X(22)00101-9 2022年9月
Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets

Kazuhiro Yamamoto, Carsten Scavenius, Maria M Meschis, Emilie H Mogensen, Abdulrahman M E Gremida, Ida B Thøgersen, Simone Bonelli, Simone D Scilabra, Salvatore Santamaria, Josefin Ahnström …

2022年3月2日
The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea

Mogensen, E.H., Poulsen, E.T., Th?gersen, I.B., Yamamoto, K., Br{\"u}el, A., Enghild, J.J.

Experimental Eye Research 219(ARTN 109081) 2022年
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis

David J. Wilkinson, Adrian M., D. Falconer, Helen L. Wrigh, Hua Lin, Kazuhiro Yamamoto, Kathleen Cheung, Sarah H. Charlton, Maria del Carmen Arques, Sabina Janciauskiene …

The FEBS Journal 289(1) 121-139 2022年1月
Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin

Seandean Lykke Harwood, Nadia Sukusu Nielsen, Khang Diep, Kathrine Tejlg{\aa}rd Jensen, Peter Kresten Nielsen, Kazuhiro Yamamoto, Jan J. Enghild

Journal of Biological Chemistry 297(1) 100879-100879 2021年7月
Identification of a novel regulator of adamts-5-mediated aggrecan degradation in chondrocytes

I. Collins, K. Yamamoto, L. Troeberg, A.K. Wann

Osteoarthritis and Cartilage 29 2021年4月
Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

K. Saini, M. Tiwari, S. Cho, A. Jalil, M. Vashisth, J. Irianto, J. Andrechak, L. Dooling, C. Alvey, A. Kasznel …

2021年2月8日

もっとみる

書籍等出版物

大腸癌の転移におけるマトリライシンの役割

(担当:共著)

Gastrointestinal Research 2006年
マトリライシンの構造と機能

日本臨床 2003年
タンパク質実験ノート第1版

(担当:分担執筆, 範囲:免疫沈降法)

羊土社
タンパク質実験ノート第２版

(担当:共著, 範囲:免疫沈降法)

羊土社

講演・口頭発表等

Fibroblast LRP1 drives pulmonary fibrosis by mediating plasma membrane collagen fibril assembly

British Society for Matrix Biology Spring Meeting, Nottingham, UK 2025年4月
The extracellular molecule clearance system in tissue homeostasis and destruction

SANTO Project: International Symposium on Osteoarthritis and Cartilage, Kanazawa University Hospital, Kanazawa, Japan 2025年3月招待有り
The extracellular molecule clearance system in tissue homeostasis and destruction

Advances in Biosciences Seminar at University of Manchester, Manchester, UK 2024年11月招待有り
Endocytic receptor LRP1 in tissue homeostasis, remodelling and destruction

CNR-Royal Society Network Meeting, Glasgow, UK 2024年7月招待有り
Tissue- and context-dependent roles of the low-density lipoprotein receptor-related protein 1 in mouse models of osteoarthritis

OARSI World Congress on Osteoarthritis, Vienna, Austria 2024年4月
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with WNT dysregulation

British Society for Matrix Biology (BSMB) Spring Meeting, Bristol, UK 2024年4月
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth

12th International Proteoglycan Conference/89th Harden Conference, Surrey, UK 2023年9月
Longitudinal microCT monitoring of mouse bones

6th Annual Symposium of the Centre for Pre-clinical Imaging, Liverpool, UK 2023年9月招待有り
Cell-surface receptor LRP1 in skeletal progenitor cells is critical for the formation of multiple skeletal elements

British Society for Matrix Biology Spring Meeting, Sheffield, UK 2023年4月
Unravelling the Molecular Mechanisms of Dental Ageing and Disease: A Proteomic Study of Equine Teeth

British Society for Matrix Biology Spring Meeting, Sheffield, UK 2023年4月
The cell-surface receptor LRP1 is a rapid responder and transducer of mechanical force

Gordon Research Conference on Cartilage and Joint Pathology, II Ciocco, Italy 2023年3月
LRP1 in skeletal precursors guides limb development through direct regulation of WNT signalling

Gordon Research Conference on Cartilage and Joint Pathology, II Ciocco, Italy 2023年3月
The cell-surface multifunctional receptor LRP1 in extracellular matrix turnover, morphogen signalling and mechano-adaptation

BIO Open Lecture series, University of East Anglia, Norwich, UK 2023年3月招待有り
The emerging roles of LRP1 in skeletal development, lung fibrosis and mechano-adaptation

CNR-Royal Society Network Meeting, University of East Anglia, Norwich, UK 2023年3月招待有り
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage

The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing Autumn Meeting, York, UK 2022年10月
LRP1 is required for the excessive collagen deposition in bleomycin-induced lung fibrosis model

Matrix Biology Europe, Florence, Italy 2022年9月
The cell-surface receptor LRP1 is a rapid responder and transducer of mechanical force

British Society for Matrix Biology Autumn Meeting, Liverpool, UK 2022年9月
Interaction of Wnts and low-density lipoprotein receptor-related protein 1 in cartilage development

British Society for Matrix Biology Autumn Meeting, Liverpool, UK 2022年9月
The low-density lipoprotein receptor-related protein 1 is essential for skeletal development

Bone Research Society Annual meeting, Manchester, UK 2022年7月
A novel function of LRP1 as a mechano-receptor in joints

Cutting Edge OA, Oxford, UK 2022年7月

もっとみる

所属学協会

2025年3月 - 現在

日本結合組織学会
2009年 - 現在

British Society for Matrix Biology
2015年 - 2025年

Biochemical Society

共同研究・競争的資金等の研究課題

Optimising the functional potential of serpins to block cartilage breakdown: Implications for novel therapeutics for osteoarthritis

Versus Arthritis Career Development Fellowship 2020年1月 - 2025年4月
改変型TIMP-3を用いた選択的軟骨破壊阻害による進行性下顎頭吸収の抑制

日本学術振興会基盤研究(C) 2021年4月 - 2024年3月
Inflammatory biomarkers in pulpal blood for teeth undergoing pulpotomy or root canal treatment.: A pilot study

University of Liverpool School of Dentistry Oral Health Research grant 2023年1月 - 2023年12月
Proteomic Profiling of Equine Teeth to Identify Age and Disease Related Differences

The Horse Trust Pump Priming Project grant 2022年11月 - 2023年10月
Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis

Versus Arthritis Bridging Fellowship 2023年4月
Shedding of the endocytic receptor LRP1 in cartilage: A novel link to the development of osteoarthritis

Arthritis Research UK Career Development Fellowship 2017年6月 - 2022年9月
Unravelling molecular basis behind mechano-transduction and adaptation of articular chondrocytes

The Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing The Starting Well, Living Well, Ageing Well theme pump-priming fund 2022年7月 - 2022年7月
Development of a novel international research team to address the pathogenesis of human temporomandibular joint disorder

Sasakawa Foundation Butterfield Awards for UK-Japan collaboration 2019年 - 2022年
To delineate the role of endocytic receptor LRP1 in OA pathogenesis in vivo

University of Liverpool Technology Directorate Voucher Scheme 2017年12月 - 2018年12月
Shedding of endocytic receptor LRP1 promotes osteoarthritis by altering extracellular trafficking of metalloproteinases

Arthritis Research UK Project Grant 2014年2月 - 2017年6月