論文

査読有り
2019年1月13日

Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction

RSC ADVANCES
  • Kobatake, Reiko
  • ,
  • Doi, Kazuya
  • ,
  • Kubo, Takayasu
  • ,
  • Makihara, Yusuke
  • ,
  • Oki, Yoshifumi
  • ,
  • Yokoi, Miyuki
  • ,
  • Umehara, Hanako
  • ,
  • Tsuga, Kazuhiro

9
3
開始ページ
1625
終了ページ
1631
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c8ra08744j
出版者・発行元
ROYAL SOC CHEMISTRY

The purpose of this study was to develop a novel porous titanium material with superior mechanical strength and osteoconduction for bone reconstruction. Porous titanium samples were fabricated by titanium-slurry impregnate to prepare urethane forms with several porosities (high-porosity; 92%, middle-porosity; 85% and low-porosity; 65%). Porous HA (mean porosity; 75.3%) was used as a control. To evaluate the characteristics of these materials, we performed porosity measurements, scanning electron microscopy (SEM), three-point bending testing, and cell proliferation assays. To evaluate the osteoconduction ability, porous titanium was placed into the femurs of rabbits and histological and histomorphometric evaluations were performed after 3 weeks. In SEM images, porous three-dimensional structures were observed in all samples. The bending strength significantly increased as porosity increased (Ti-65 > Ti-85 > porous HA > Ti-92, P < 0.05; respectively). Ti-65, Ti-85, and porous HA showed good cell proliferation. Newly formed bone was observed in the central portion of Ti-65, Ti-85, and porous HA. Ti-92 was mainly detected in the bone marrow tissue. The bone formation areas of Ti-65, Ti-85, and porous HA were significantly higher than that of Ti-92 (P < 0.05). It was suggested that novel developed porous titanium composed of Ti-65 and Ti-85 showed superior mechanical strength and osteoconduction.

リンク情報
DOI
https://doi.org/10.1039/c8ra08744j
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000457292800051&DestApp=WOS_CPL
ID情報
  • DOI : 10.1039/c8ra08744j
  • ISSN : 2046-2069
  • Web of Science ID : WOS:000457292800051

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