Kazuhiro Wada
(和多 和宏)Profile Information
- Affiliation
- Professor, Faculty of Science, Hokkaido University
- Degree
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博士(医学)(Jan, 2005, 東京医科歯科大学)
- Researcher number
- 70451408
- J-GLOBAL ID
- 201101094103787000
- researchmap Member ID
- B000002050
- External link
The goal of my laboratory is to elucidate the molecular and genetic mechanisms underlying vocal learning, the critical/sensitive period, and species-specific learning constraints, using “songbirds (Passeriformes Oscines)”. Songbirds are known to learn species-specific songs in the early stage of their life, and the learning strategy varies among different species. One of our research interests is to elucidate the evolution of vocal learning and vocal phenotype is accompanied by advantageous gene evolution at cis/trans-regulation that control species-specific regulation of gene expression.
We are also focusing on the singing-induced genes which were expressed at higher levels by singing in juveniles than adults, in song learning brain areas. Although the singing ability of songbirds is not dependent of their age (both the juveniles and adults can sing), they have a critical period of learning songs, which is also known in human language acquisition: the younger, the easier to master languages. Behavioral, developmental, and area-specific gene expressions should be regulated by various combinations of transcription factors via multi-cis-regulatory elements with epigenetic modifications, such as histone modifications and DNA methylation. Individual experiences and surrounding environments on their life should leave epigenetic codes on their genomic DNA, which are also ruled by the species-specific genome sequences, including species-specific regulatory elements for gene expressions. Thus, I believe that the study of the regulation of these promoters in songbirds will be significantly beneficial to elucidate molecular and genetic mechanisms underlying the critical periods for learning, individual behavior difference and species-specific behaviors.
Research Interests
12Research Areas
4Research History
4-
Apr, 2010 - Sep, 2021
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Apr, 2007 - Mar, 2010
Papers
53-
Cerebral Cortex Communications, Nov 18, 2022 Peer-reviewed
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The Journal of comparative neurology, 530(11) 1966-1991, Aug 1, 2022 Peer-reviewedLast authorCorresponding author
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Molecular Brain, 14(1) 160-160, Nov, 2021 Peer-reviewedLast authorCorresponding author
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Current Biology, 31(13) 2796-2808, Jul, 2021 Peer-reviewed
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Virus Evolution, 7(1) veab003, Feb, 2021 Peer-reviewed
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Developmental Neurobiology, 80 132-146, Mar, 2020 Peer-reviewed
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Scientific Reports, 10(1) 2248, Feb, 2020 Peer-reviewed
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Proceedings of the National Academy of Sciences, 116(45) 22833-22843, Nov 5, 2019 Peer-reviewedLast authorCorresponding author
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PLoS Biology, 17(11) e3000476, Nov, 2019 Peer-reviewedLast authorCorresponding author
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Neuroscience, 409 222-234, Jun, 2019 Peer-reviewed
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Scientific Reports, 8(1) 8732, Dec 1, 2018 Peer-reviewedLast authorCorresponding author
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PLoS Biology, 16(9) e2006537, Sep, 2018 Peer-reviewedLast authorCorresponding author
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Journal of Comparative Neurology, 8(1) 8732, Sep, 2018 Peer-reviewedLast authorCorresponding author
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Developmental Neurobiology, 78(7) 671-686, Jul 1, 2018 Peer-reviewed
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European Journal of Neuroscience, 48(2) 1728-1742, Jul, 2018 Peer-reviewedLast authorCorresponding author
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PLOS ONE, 12(1) e0169643, Jan, 2017 Peer-reviewed
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JOURNAL OF NEUROSCIENCE METHODS, 271 25-33, Sep, 2016 Peer-reviewedLast authorCorresponding author
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SCIENTIFIC REPORTS, 6 30323, Jul, 2016 Peer-reviewedLast authorCorresponding author
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EXPERIMENTAL ANIMALS, 64(3) 221-230, Jul, 2015 Peer-reviewedLast authorCorresponding author
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JOURNAL OF EXPERIMENTAL BIOLOGY, 218(14) 2260-2268, Jul, 2015 Peer-reviewedLast authorCorresponding author
Misc.
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遺伝, 64(6) 40-47, Nov, 2010
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中山科学振興財団活動報告書, 2007 42-47, 2007
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比較生理生化学, 23(3) 170-172, 2006
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比較生理生化学, 18(1) 50-51, Apr 30, 2001
Books and Other Publications
6-
Springer, 2013
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新曜社, 2012
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裳華房, 2011
Research Projects
14-
科学研究費助成事業 挑戦的研究(開拓), 日本学術振興会, Jul, 2021 - Mar, 2025
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021
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Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2020
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科学研究費助成事業 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2017 - Mar, 2019
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新学術領域研究(記憶ダイナミクス), 文部科学省: 科学研究費補助金, Apr, 2016 - Mar, 2018
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基盤研究(B), 文部科学省: 科学研究費補助金, Apr, 2013 - Mar, 2016
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科学研究費補助金 挑戦的萌芽研究, 文部科学省, Apr, 2013 - Mar, 2016
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科学研究費補助金 挑戦的萌芽研究, 文部科学省, Apr, 2010 - Mar, 2013
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科学研究費補助金(新学術領域研究(研究領域提案型)), 文部科学省, Apr, 2009 - Mar, 2013
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科学研究費補助金(若手研究(A)), 文部科学省, Apr, 2009 - Mar, 2012
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科学研究費補助金(特定領域研究), 文部科学省, Apr, 2008 - Mar, 2010
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科学研究費補助金(特別研究促進費, 基盤研究(C)), 文部科学省, Apr, 2007 - Mar, 2009