論文

査読有り
2017年3月

Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
  • Daichi Ijiri
  • ,
  • Said Shimamoto
  • ,
  • Mana Kawaguchi
  • ,
  • Airi Furukawa
  • ,
  • Kazuki Nakashima
  • ,
  • Osamu Tada
  • ,
  • Akira Ohtsuka

205
開始ページ
8
終了ページ
14
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbpa.2016.12.014
出版者・発行元
ELSEVIER SCIENCE INC

The aim of this study was to examine the effects of first exogenous nutrients on the mRNA levels of muscle atrophy F-box (atrogin-1/MAFbx) and glucose transporters (GLUTs) in the skeletal muscles of newly hatched chicks with no feed experience. In experiment 1, newly hatched chicks had free access to feed or were fasted for the first 24 h. The chicks having free access to feed for the first 24 h increased their body weight and had decreased atrogin-1/MAFbx mRNA levels in their sartorius and pectoralis major muscles compared with the fasted chicks. In experiment 2, newly hatched chicks received a single feed via intubation into the crop. Three hours after intubation, levels of atrogin-1/MAFbx mRNA in the sartorius muscle were decreased whereas the plasma insulin concentration and phosphorylated Ala levels in the sartorius muscle were increased. In addition, the mRNA levels of GLUT1 and GLUT8 were increased in the-sartorius muscle after the intubation. However, in the pectoralis major muscle, ART phosphorylation and levels of atrogin-1/MAFbx, GLUT1 and GLUT8 mRNA were not affected 3 h after intubation. The first exogenous nutrients increased the level of phosphorylated ART in the sartorius muscle of newly hatched chicks, possibly because of the decrease in atrogin-1/MAFbx mRNA levels. Furthermore, the sartorius muscle in newly hatched chicks appeared to be more susceptible to the first feed compared with the pectoralis major muscle.(C) 2016 Published by Elsevier Inc.


リンク情報
DOI
https://doi.org/10.1016/j.cbpa.2016.12.014
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27989496
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394478100002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cbpa.2016.12.014
  • ISSN : 1095-6433
  • eISSN : 1531-4332
  • PubMed ID : 27989496
  • Web of Science ID : WOS:000394478100002

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