2013年11月
Disassembly-driven Turn-on Sensing of Enzyme Activity by Substrate-based Fluorescent Nanoprobe
CHEMISTRY LETTERS
- ,
- ,
- ,
- 巻
- 42
- 号
- 11
- 開始ページ
- 1426
- 終了ページ
- 1428
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.130697
- 出版者・発行元
- CHEMICAL SOC JAPAN
Herein, we report a novel signal-amplifiable self-assembling fluorescent nanoprobe for turn-on detection of specific enzyme activity. This probe employed a substrate of matrix metalloproteinase 2 (MMP2) together with a self-assembling unit, and showed a detection limit of less than 830 pM, which is 84-fold lower than that of our previous ligand-tethered fluorescent nanoprobes. Using this new probe, we succeeded in monitoring the specific activity of secreted MMP even in the conditioned media of tumor cells.
- リンク情報
- ID情報
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- DOI : 10.1246/cl.130697
- ISSN : 0366-7022
- eISSN : 1348-0715
- Web of Science ID : WOS:000328098300032