2012年10月
High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: The Toranomon Hospital Health Management Center Study 8 (TOPICS 8)
Diabetic Medicine
- 巻
- 29
- 号
- 10
- 開始ページ
- 1285
- 終了ページ
- 1290
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1464-5491.2012.03667.x
Aims We aimed to characterize the association of insulin resistance, impaired insulin secretion and β-cell dysfunction in relation to HbA1c levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. Methods This cross-sectional study included 1444 individuals without a history of outpatient treatment of diabetes or use of insulin or oral hypoglycaemic agents. The homeostasis model assessment of insulin resistance and beta-cell function, insulinogenic index, Matsuda index and disposition index were calculated using data from 75-g oral glucose tolerance tests and compared across quintile (Q) categories of HbA1c levels. Results Fasting plasma glucose and 30-min and 60-min plasma glucose (PG) levels were significantly higher when HbA1c exceeded 36mmol/mol (5.4%). A HbA1c concentration of 36-37mmol/mol (5.4-5.5%) (Q3) was significantly associated with a 15% lower homeostasis model assessment of β-cell function value and 31% lower insulinogenic index value compared with HbA1c≤32mmol/mol (≤5.1%) (Q1) (P<
0.01). Further, a HbA1c concentration of 38-40mmol/mol (5.6-5.8%) (Q4) was associated with 17% (P<
0.01) and 24% (P<
0.05) reductions in those indexes, respectively. However, the homeostasis model assessment of insulin resistance was not significantly elevated and the Matsuda index was not significantly lower unless HbA1c exceeded 41mmol/mol (5.9%). Individuals with HbA1c≥41mmol/mol (≥5.9%) (Q5) had a 69% lower disposition index than those with a HbA1c concentration of ≤32mmol/mol (≤5.1%) (Q1). Conclusions Elevated HbA1c levels ≥41mmol/mol (≥5.9%) were associated with substantial reductions in insulin secretion, insulin sensitivity and β-cell dysfunction in Japanese individuals not treated for diabetes. High normal HbA1c levels of 36-40mmol/mol (5.4-5.8%) were also associated with impaired insulin secretion without marked insulin resistance in Japanese individuals. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.
0.01). Further, a HbA1c concentration of 38-40mmol/mol (5.6-5.8%) (Q4) was associated with 17% (P<
0.01) and 24% (P<
0.05) reductions in those indexes, respectively. However, the homeostasis model assessment of insulin resistance was not significantly elevated and the Matsuda index was not significantly lower unless HbA1c exceeded 41mmol/mol (5.9%). Individuals with HbA1c≥41mmol/mol (≥5.9%) (Q5) had a 69% lower disposition index than those with a HbA1c concentration of ≤32mmol/mol (≤5.1%) (Q1). Conclusions Elevated HbA1c levels ≥41mmol/mol (≥5.9%) were associated with substantial reductions in insulin secretion, insulin sensitivity and β-cell dysfunction in Japanese individuals not treated for diabetes. High normal HbA1c levels of 36-40mmol/mol (5.4-5.8%) were also associated with impaired insulin secretion without marked insulin resistance in Japanese individuals. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.
- リンク情報
- ID情報
-
- DOI : 10.1111/j.1464-5491.2012.03667.x
- ISSN : 0742-3071
- ISSN : 1464-5491
- PubMed ID : 22486679
- SCOPUS ID : 84866437534