論文

査読有り 本文へのリンクあり 国際誌
2016年10月1日

The feasibility of 11 C-PIB-PET/CT for amyloid plaque burden: validation of the effectiveness of CT-based partial volume correction

Brain and Behavior
  • Kei Sasaki
  • ,
  • Norihide Maikusa
  • ,
  • Etsuko Imabayashi
  • ,
  • Tetsuya Yuasa
  • ,
  • Hiroshi Matsuda

6
10
開始ページ
e00532
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/brb3.532
出版者・発行元
WILEY

© 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. Introduction: Amyloid positron-emission tomography (PET) imaging with 11 C-Pittsburgh compound B (PiB) is an effective tool for assessing brain amyloid deposits. PET imaging, however, can suffer from the partial volume effect (PVE). PVE has been corrected using MRI (magnetic resonance imaging) image data. However, correction of the PVE of PET using MRI usually requires two separate procedures, imposing a burden on patients and leading to low throughput and inefficient diagnoses. The advent of PET/computed tomography (PET/CT) may potentially overcome these problems and offer higher throughput and reliable quantification of amyloid plaques and assessment of Alzheimer disease (AD). Methods: We investigated the feasibility of correcting PVE in amyloid PET using CT, obtained by PET/CT, instead of MRI. We demonstrated the efficacy of partial volume correction (PVC) based on CT by comparing the results of CT-based PVC and those of MRI-based PVC using images acquired from AD patients and controls. Results: Both methods were able to perform PVC. Slight but significant differences between standard uptake volume ratio (SUVR) values were noted between the two modalities; these were attenuated by constant multiplication. Conclusion: CT will potentially replace MRI for PVC, allowing the use of a single PET/CT scanner for amyloid plaque quantitation.

リンク情報
DOI
https://doi.org/10.1002/brb3.532
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27781145
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064343
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000387586800017&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979979896&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84979979896&origin=inward
ID情報
  • DOI : 10.1002/brb3.532
  • ISSN : 2162-3279
  • eISSN : 2162-3279
  • PubMed ID : 27781145
  • PubMed Central 記事ID : PMC5064343
  • SCOPUS ID : 84979979896
  • Web of Science ID : WOS:000387586800017

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