論文

2022年8月23日

Millimetre-scale magnetocardiography of living rats with thoracotomy

Communications Physics
  • Keigo Arai
  • Akihiro Kuwahata
  • Daisuke Nishitani
  • Ikuya Fujisaki
  • Ryoma Matsuki
  • Yuki Nishio
  • Zonghao Xin
  • Xinyu Cao
  • Yuji Hatano
  • Shinobu Onoda
  • Chikara Shinei
  • Masashi Miyakawa
  • Takashi Taniguchi
  • Masatoshi Yamazaki
  • Tokuyuki Teraji
  • Takeshi Ohshima
  • Mutsuko Hatano
  • Masaki Sekino
  • Takayuki Iwasaki
  • 全て表示

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1
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42005-022-00978-0
出版者・発行元
Springer Science and Business Media LLC

Abstract

Magnetocardiography is a contactless imaging modality for electric current propagation in the cardiovascular system. Although conventional sensors provide sufficiently high sensitivity, their spatial resolution is limited to a centimetre-scale, which is inadequate for revealing the intra-cardiac electrodynamics such as rotational waves associated with ventricular arrhythmias. Here, we demonstrate invasive magnetocardiography of living rats at a millimetre-scale using a quantum sensor based on nitrogen-vacancy centres in diamond. The acquired magnetic images indicate that the cardiac signal source is well explained by vertically distributed current dipoles, pointing from the right atrium base via the Purkinje fibre bundle to the left ventricular apex. We also find that this observation is consistent with and complementary to an alternative picture of electric current density distribution calculated with a stream function method. Our technique will enable the study of the origin and progression of various cardiac arrhythmias, including flutter, fibrillation, and tachycardia.

リンク情報
DOI
https://doi.org/10.1038/s42005-022-00978-0
URL
https://www.nature.com/articles/s42005-022-00978-0.pdf
URL
https://www.nature.com/articles/s42005-022-00978-0
ID情報
  • DOI : 10.1038/s42005-022-00978-0
  • eISSN : 2399-3650

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