Keiichi ASANO - My portal

Profile Information

Affiliation: Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba

Degree: PhD in Medical Science(Mar, 2018, Okayama University)

Researcher number: 10985641
J-GLOBAL ID: 202301002538423069
researchmap Member ID: R000051069

External link: https://scholar.google.com/citations?user=sSOGv5QAAAAJ&hl=en&authuser=1

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
Apr, 2023 - Present

Assistant Professor, Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
Apr, 2018 - Mar, 2023

Postdoctoral Researcher, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Apr, 2018 - Mar, 2023

Postdoctoral Fellow, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Apr, 2018 - Mar, 2019

Guest Investigator, Medical School, Okayama University

Education

- Mar, 2018

Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Committee Memberships

Jun, 2023 - Jun, 2024

第56回日本結合組織学会学術大会大会組織委員（庶務）, 日本結合組織学会

Awards

Papers

Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice

Hossain, ASM Sakhawa, Clarin, Maria Thea, Rane, Dela Cruz, Kimura, Kenichi, Biggin, George, Taga, Yuki, Uto, Koichiro …

MATRIX BIOLOGY, 135 24-38, Feb, 2025
Fibrillin-1 deficiency perturbs aortic cholinergic relaxation and adrenergic contraction in a mouse model of early onset progressively severe Marfan syndrome

Cantalupo, Anna, Asano, Keiichi, Dikalov, Sergey, Gordon, Dylan, Ramirez, Francesco

Journal of vascular research, 1-21, Jan, 2025
A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Clarin, Maria Thea, Rane, Dela Cruz, Raja, Erna …

Biorxiv, May, 2024
Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells.

Yifei Sun, Keiichi Asano, Lauriane Sedes, Anna Cantalupo, Jens Hansen, Ravi Iyengar, Martin J Walsh, Francesco Ramirez

JCI insight, Apr 6, 2023
Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome.

Lauriane Sedes, Elisa Wondimu, Brittany Crockett, Jens Hansen, Anna Cantalupo, Keiichi Asano, Ravi Iyengar, Daniel B Rifkin, Silvia Smaldone, Francesco Ramirez

Human molecular genetics, 31(19) 3281-3289, Sep 29, 2022
The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology.

Keiichi Asano, Anna Cantalupo, Lauriane Sedes, Francesco Ramirez

International journal of molecular sciences, 23(3), Feb 8, 2022
Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome.

Keiichi Asano, Anna Cantalupo, Lauriane Sedes, Francesco Ramirez

Biomolecules, 12(1), Jan 14, 2022
Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis.

Takashi Ohtsuki, Omer F Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, Satoshi Hirohata

International journal of molecular sciences, 21(9), Apr 29, 2020
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.

Takashi Ohtsuki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Keiichi Asano, Omer Faruk Hatipoglu, Junko Inagaki, Ken Takahashi, Toshitaka Oohashi, Keiichiro Nishida, Keiji Naruse …

Experimental cell research, 383(2) 111556-111556, Oct 15, 2019
High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression.

Takashi Ohtsuki, Keiichi Asano, Junko Inagaki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Mehmet Z Cilek, Omer F Hatipoglu, Toshitaka Oohashi, Keiichiro Nishida, Issei Komatsubara …

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(12) 3247-3255, Dec, 2018
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.

Keiichi Asano, Midori Edamatsu, Omer F Hatipoglu, Junko Inagaki, Mitsuaki Ono, Takashi Ohtsuki, Toshitaka Oohashi, Satoshi Hirohata

Acta medica Okayama, 72(3) 257-266, Jun, 2018
Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.

Keiichi Asano, Courtney M Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J Lindner, Tyler Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Suneel S Apte …

Scientific reports, 7(1) 17225-17225, Dec 8, 2017
ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor.

Junko Inagaki, Katsuyuki Takahashi, Hiroko Ogawa, Keiichi Asano, Omer Faruk Hatipoglu, Mehmet Zeynel Cilek, Masanari Obika, Takashi Ohtsuki, Matthias Hofmann, Shozo Kusachi …

Experimental cell research, 323(2) 263-75, May 1, 2014

Misc.

変形性関節症関連microRNAの検索並びに解析

大月孝志, オメル・ファルク・ハティポール, 品岡玲, メフメット・ゼイネル・チレッキ, 西村拓人, 浅野恵一, 稲垣純子, 大橋俊孝, 西田圭一郎, 岡田保典 …

日本結合組織学会学術大会プログラム・抄録集, 50回 111-111, Jun, 2018
がん微小環境の実体がん微小環境におけるバーシカン分解酵素ADAMTSの局在と血管新生におけるバーシカンの意義

浅野恵一, 廣畑聡, 大月孝志, オメル・ファルク・ハティポール, 稲垣純子, 大橋俊孝

日本結合組織学会学術大会プログラム・抄録集, 49回 56-56, Jun, 2017
変形性関節症へのヒアルロン酸投与、いつ投与すべきか? 動物モデルからの知見

大月孝志, 品岡玲, 熊岸加苗, 河野真優美, 篠原真歩, 浅野恵一, 稲垣純子, 大橋俊孝, 西田圭一郎, 廣畑聡

日本結合組織学会学術大会プログラム・抄録集, 48回 60-60, Jun, 2016
伸展刺激の強度による細胞外マトリックスタンパクおよびマトリックス分解酵素発現への影響

大月孝志, 金道幸子, 長谷川みさ, 稲垣純子, 浅野恵一, 障子友理, 熊岸加苗, 西田圭一郎, 大橋俊孝, 廣畑聡

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P0078]-[2P0078], Dec, 2015
ADAMTSによるバーシカン分解と腫瘍内血管新生の関連

浅野恵一, 稲垣純子, 障子友理, Hofmann Matthias, 大月孝志, 廣畑聡, 大橋俊孝

日本結合組織学会学術大会プログラム・抄録集, 47回 114-114, May, 2015
メカニカルストレスが軟骨様細胞の細胞外マトリックス及びマトリックス分解酵素のmRNA発現へ示す効果の検討

大月孝志, 金道幸子, 長谷川みさ, 平田彩, 川地輝幸, 浅野恵一, 稲垣純子, 障子友理, 熊岸加苗, 西田圭一郎 …

日本結合組織学会学術大会プログラム・抄録集, 47回 134-134, May, 2015
ADAMTS1はVEGFCと結合してリンパ管新生を抑制する

稲垣純子, 高橋克之, 小川弘子, 浅野恵一, Hatipoglu Omer Faruk, Cile Mehmet Zeynel, 小比賀真就, 大月孝志, Hofmann Matthias, 草地省蔵 …

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 46回・61回 137-137, Jun, 2014
ヒアルロン酸短期投与によるラット変形性関節症モデルの関節軟骨保護効果の検討

大月孝志, 廣畑聡, 障子友理, 浅野恵一, 平田彩, 川地輝幸, 稲垣純子, 熊岸加苗, 西田圭一郎, 二宮善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 46回・61回 107-107, Jun, 2014
ヒアルロン酸(HA)分子量と関節軟骨保護効果の解析(in vivo & in vitro)

大月孝志, 廣畑聡, 浅野恵一, 楠絵理子, 稲垣純子, 西田圭一郎, 二宮善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 45回・60回 74-74, Jun, 2013

Books and Other Publications

生体の科学 75巻4号

浅野, 恵一

Aug, 2024
実験医学別冊実験デザインからわかるシングルセル研究実践テキスト

浅野, 恵一

羊土社, Mar, 2024 (ISBN: 9784758122702)

Presentations

遺伝性胸部大動脈疾患におけるメカノトランスダクション異常

柳沢裕美, 木村健一, 本山絵理, 浅野恵一, 神吉佐知子

CVMW 2024
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

CVMW 2024
トロンボスポンジン１はメカニカルストレス応答因子として大動脈壁恒常性の維持に関わる

Zou, Chenlu, 浅野, 恵一, 柳沢, 裕美

第8回エラスチン・関連分子研究会学術集会
フィブリリン１遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析

本山絵理, 木村, 健一, 浅野恵一, 神吉佐知子, 中邨智之, 柳沢裕美

第8回エラスチン・関連分子研究会
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

第47回日本分子生物学会年会
Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis

Sheikh, Md Al Amin, Kimura, Kenichi, Motoyama, Eri, Deleeuw, Violette, Kanki, Sachiko, Asano, Keiichi, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Ozaki, Haruka, Yanagisawa, Hiromi

Tsukuba Global Science Week 2024
血管平滑筋細胞のメカノセンシング異常が大動脈恒常性に及ぼす影響

Zou, Chenlu, 浅野, 恵一, 柳沢, 裕美

第10回MatriCellフォーラム
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.

Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Deleeuw, Violette, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

International Vascular Biology Meeting 2024
Investigation of mechanosensing mechanisms in aortic dissection caused by a missense variant in the fibrillin-1

本山, 絵理, 木村, 健一, Maria, Thea Rane, Dela Cruz Clarin, 浅野, 恵一, 神吉, 佐智子, 柳沢, 裕美

第56回日本結合組織学会学術大会
Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis

Sheikh, Md Al Amin, Kimura, Kenichi, Motoyama, Eri, Deleeuw, Violette, Kanki, Sachiko, Asano, Keiichi, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Yanagisawa, Hiromi

第56回日本結合組織学会学術大会
Fibrillin-1 G234D mutation links mouse skin tightness to elastic fiber defects and collagen cross-linking

Hossain, ASM Sakhawa, Cruz, Maria Thea Rane Dela, Kimura, Kenichi, Taga, Yuki, Uto, Koichiro, Yamagishi, Ayana, Motoyama, Eri, Mizuno, Kazunori, Nakamura, Chikashi, Asano, Keiichi, Ohtsuki, Sumio, Nakamura, Tomoyuki, Kanki, Sachiko, Raja, Erna, Yanagisawa, Hiromi

第56回日本結合組織学会学術大会
Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection

Cruz, Maria Thea Rane Dela, Motoyama, Eri, Ahmed, Nabil, Uto, Koichiro, Kanki, Sachiko, Kimura, Kenichi, Asano, Keiichi, Ebara, Mitsuhiro, Yanagisawa, Hiromi

第56回日本結合組織学会学術大会
Investigation of the molecular pathogenesis of aortic dissection in Fibrillin-1 mutant mice by synchrotron imaging and transcriptomics analysis

Sheikh, Md Al Amin, Kimura, Kenichi, Motoyama, Eri, Deleeuw, Violette, Kanki, Sachiko, Asano, Keiichi, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Ozaki, Haruka, Yanagisawa, Hiromi

第7回日本循環器学会基礎研究フォーラム（BCVR）
A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes Tight Skin Phenotype

ASM, Sakhawat Hossain, Maria, Thea Rane, Dela Cruz, Koichiro, Uto, Eri, Motoyama, Sumio, Ohtsuki, Keiichi, Asano, Kenichi, Kimura, Yuki, Taga, Kazunori, Mizuno, Tomoyuki, Nakamura, Sachiko, Kanki, Erna, Raja, Hiromi, Yanagisawa

第7回エラスチン・関連分子研究会学術集会
A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes an Abnormal Skin Phenotype

ASM, Sakhawat Hossain, Yuki, Taga, Maria, Thea Rane, Dela Cruz, Kazunori, Mizuno, Koichiro, Uto, Eri, Motoyama, Sumio, Ohtsuki, Keiichi, Asano, Kenichi, Kimura, Tomoyuki, Nakamura, Sachiko, Kanki, Erna, Raja, Hiromi, Yanagisawa

Tissue, Matrix, and Pathobiology: Joint Meeting of ASMB, HCS, and ASIP
Investigation of the molecular pathogenesis of aortic dissection in Fibrillin-1 mutant mice by synchrotron imaging and transcriptomics analysis

Sheikh, Md Al Amin, Kimura, Kenichi, Motoyama, Eri, Deleeuw, Violette, Kanki, Sachiko, Asano, Keiichi, Sips, Patrick, Backer, Julie De, Sakai, Lynn Y., Ozaki, Haruka, Yanagisawa, Hiromi

the annual Tsukuba Global Science Week (TGSW) 2023
Angiotensin receptors as therapeutic targets for thoracic aortic aneurysm and acute dissection in Marfan syndrome

KEIICHI ASANO

The 55th Annual Meeting of the Japanese Society for Matrix Biology and Medicine, Jun 25, 2023 Invited
Fibrillin-1 deletion in endothelial cells replicates early events promoting arterial disease in Marfan syndrome

Cantalupo, Anna, Asano, Keiichi, Dikalov, Sergey, Halabi, Carmen, Mecham, Rober, Di Lorenzo, Annarita, Iyengar, Ravi, Ramirez, Francesco

22nd International Vascular Biology Meeting
Identification of unique cell populations associated with thoracic aortic aneurysm of Marfan syndrome mice

Asano, Keiichi, Sun, Yifei, Cantalupo, Anna, Sedes, Lauriane, Walsh, Martin, J, Ramirez, Francesco

22nd International Vascular Biology Meeting
LOSS OF TGFβ SIGNALING IN THE OUTER PERICHONDRIUM CAUSES LONGITUDINAL BONE OVERGROWTH IN MARFAN SYNDROME

Sedes Lauriane, Wondimu Elisa, Cantalupo Anna, Asano Keiichi, Hansen Jens, Iyengar Ravi, Rifkin Daniel, Smaldone Silvia, Ramirez Francesco

The Marfan Foundation Presents Science in Paris

Teaching Experience

2023 - Present

Topics in Vascular Biology (University of Tsukuba)
2023 - Present

Research Presentation and Discussion (University of Tsukuba)

Professional Memberships

2022 - Present

North American Vascular Biology Organization
2015 - Present

Japanese Society for Matrix Biology and Medicine
2014 - Present

American Society for Matrix Biology

Research Projects

平滑筋細胞の形質転換は大動脈瘤の新規治療標的となりうるか？

若手研究, 文部科学省科研費日本学術振興会, Apr, 2024 - Mar, 2028

浅野恵一
マルチオミクス解析から紐解く大動脈解離の発症機序

研究奨励金, 上原記念生命科学財団

浅野恵一