論文

査読有り
2016年10月

Rational design of novel high molecular weight solubilization surfactants for membrane proteins from the peptide gemini surfactants (PG-surfactants)

TETRAHEDRON
  • Shuhei Koeda
  • ,
  • Tomoyuki Suzuki
  • ,
  • Tomoyasu Noji
  • ,
  • Keisuke Kawakami
  • ,
  • Shigeru Itoh
  • ,
  • Takehisa Dewa
  • ,
  • Nobuo Kamiya
  • ,
  • Toshihisa Mizuno

72
43
開始ページ
6898
終了ページ
6908
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tet.2016.09.024
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

We successfully developed novel high molecular weight (Mw) solubilization surfactants for membrane proteins, Bis-D-3-DEDKC12 (Mw similar to 3 kDa), Bis-K-3-DICDKC12 (Mw similar to 3 kDa), and Tris-D-3-DICDKC12 (Mw similar to 4.3 kDa), which were rationally designed from our previously established peptide gemini surfactants (PG-surfactants) DKDKC12K and DICIDIT12D (Mw similar to 1.3 kDa). An increase in Mw enhanced affinity between membrane proteins and surfactants, thereby allowing effective solubilization, even for lower concentration ranges (<0.0005 wt%). (C) 2016 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.tet.2016.09.024
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385322800016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.tet.2016.09.024
  • ISSN : 0040-4020
  • Web of Science ID : WOS:000385322800016

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