論文

査読有り 国際誌
2019年

Histone acetylation orchestrates wound-induced transcriptional activation and cellular reprogramming in Arabidopsis.

Communications biology
  • Bart Rymen
  • Ayako Kawamura
  • Alice Lambolez
  • Soichi Inagaki
  • Arika Takebayashi
  • Akira Iwase
  • Yuki Sakamoto
  • Kaori Sako
  • David S Favero
  • Momoko Ikeuchi
  • Takamasa Suzuki
  • Motoaki Seki
  • Tetsuji Kakutani
  • François Roudier
  • Keiko Sugimoto
  • 全て表示

2
開始ページ
404
終了ページ
404
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-019-0646-5

Plant somatic cells reprogram and regenerate new tissues or organs when they are severely damaged. These physiological processes are associated with dynamic transcriptional responses but how chromatin-based regulation contributes to wound-induced gene expression changes and subsequent cellular reprogramming remains unknown. In this study we investigate the temporal dynamics of the histone modifications H3K9/14ac, H3K27ac, H3K4me3, H3K27me3, and H3K36me3, and analyze their correlation with gene expression at early time points after wounding. We show that a majority of the few thousand genes rapidly induced by wounding are marked with H3K9/14ac and H3K27ac before and/or shortly after wounding, and these include key wound-inducible reprogramming genes such as WIND1, ERF113/RAP2.6 L and LBD16. Our data further demonstrate that inhibition of GNAT-MYST-mediated histone acetylation strongly blocks wound-induced transcriptional activation as well as callus formation at wound sites. This study thus uncovered a key epigenetic mechanism that underlies wound-induced cellular reprogramming in plants.

リンク情報
DOI
https://doi.org/10.1038/s42003-019-0646-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31701032
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828771
ID情報
  • DOI : 10.1038/s42003-019-0646-5
  • PubMed ID : 31701032
  • PubMed Central 記事ID : PMC6828771

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