Keisuke Ueda

Profile Information

Affiliation: Graduate School of Pharmaceutical Sciences, Chiba University

Degree: 博士(薬科学)(千葉大学)

Researcher number: 40755972
J-GLOBAL ID: 201801013807724668
researchmap Member ID: B000304831

External link: http://www.p.chiba-u.jp/lab/seizai/index.html

Research Interests

Research Areas

Life sciences / Pharmaceuticals - analytical and physicochemistry /

Research History

Apr, 2015 - Present

Assistant Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Jun, 2019 - Mar, 2020

IPPH, Department of Industrial and Physical Pharmacy, Purdue University
Apr, 2014 - Mar, 2015

Research Fellowship for Young Scientists, Japan Society for the Promotion of Science

Committee Memberships

Aug, 2023

実行委員, 製剤機械技術学会：第31回講演会
Nov, 2022

実行委員, 4th international symposium on BA/BE of oral drug products, 2022
2018 - 2022

英語セミナー委員, 日本薬剤学会
Jul, 2021

実行委員長, APSTJ Global Education Seminar 2021 1 st
Jun, 2021

実行委員, 第３７回日本DDS学会学術集会
2017 - 2021

執行部, 日本薬剤学会経口吸収FG
Mar, 2019

組織委員, 日本薬学会第139年会

Awards

May, 2022

日本薬剤学会奨励賞, 日本薬剤学会
Oct, 2015

製剤と粒子設計シンポジウム奨励賞, 第32回製剤と粒子設計シンポジウム
Aug, 2015

Postdoctoral Presentation Award, 第40回製剤・創剤セミナー
May, 2015

最優秀発表者賞, 日本薬剤学会第30年会
Mar, 2015

学長表彰, 千葉大学
Mar, 2015

日本薬学会第135年会優秀発表賞, 日本薬学会
Mar, 2014

日本薬学会第134年会優秀発表賞, 日本薬学会
Oct, 2013

製剤機械技術学会第23回大会優秀ポスター賞, 製剤機械技術学会
Mar, 2012

日本薬学会第133年会優秀発表賞, 日本薬学会

Papers

NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP.

Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Fumie Sakuma, Hiroki Tanaka, Hidetaka Akita, Kenjirou Higashi, Kunikazu Moribe

Journal of controlled release : official journal of the Controlled Release Society, 373 738-748, Aug 2, 2024
Effect of Acetaminophen on Poloxamer 407 Micelles and Hydrogels: The Relationship between Structural and Physical Properties

Fumie Sakuma, Kenjirou Higashi, Keisuke Ueda, Takeshi Morita, Daisuke Iohara, Fumitoshi Hirayama, Kunikazu Moribe

Langmuir, Jul 16, 2024
Voices in Molecular Pharmaceutics: Meet Professor Keisuke Ueda, Who Scrutinizes the Molecular-Level Properties of Drugs and Formulations Using NMR Spectroscopy.

Keisuke Ueda

Molecular pharmaceutics, Apr 17, 2024
Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid-Liquid Phase Separation.

Etsushi Yoshikawa, Keisuke Ueda, Rei Hakata, Kenjirou Higashi, Kunikazu Moribe

Molecular pharmaceutics, 21(4) 1745-1755, Apr 1, 2024
Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles.

Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Koichi Wada, Kunikazu Moribe

Molecular pharmaceutics, 21(3) 1424-1435, Mar 4, 2024
Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR.

Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe

Molecular pharmaceutics, 21(3) 1501-1514, Mar 4, 2024
The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles.

Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi …

Pharmaceutics, 16(2), Jan 26, 2024
Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses.

Kazunori Kadota, Tero Kämäräinen, Fumie Sakuma, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Hiromasa Uchiyama, Katsuhiko Minoura, Yuichi Tozuka

Food & function, 14(23) 10493-10505, Nov 8, 2023
Crystallization of Amorphous Nifedipine Under Isothermal Conditions: Inter-laboratory Reproducibility and Investigation of the Factors Affecting Reproducibility.

Tamaki Miyazaki, Ryo Mizoguchi, Keisuke Ueda, Taeko Shinozaki, Mie Kamoto, Yoshihiro Takeda, Satoshi Sakuma, Naoya Ito, Michiko Momo, Kohsaku Kawakami

Journal of pharmaceutical sciences, 112(10) 2703-2716, Oct, 2023
Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by 1H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties.

Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Taiki Fujimoto, Misaki Nakamura, Fumie Sakuma, Shun Kaneko, Taisei Tokumoto, Koki Nishimura, Junpei Takeda …

Molecular pharmaceutics, 20(9) 4729-4742, Sep 4, 2023
Introducing the Molecular Pharmaceutics Virtual Special Issue on "Advances in Molecular Pharmaceutical Research from Asia".

Keisuke Ueda, Ting Cai, Swati Biswas, Sun Hwa Kim

Molecular pharmaceutics, 20(8) 3694-3695, Aug 7, 2023
Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption.

Yuta Hatanaka, Hiromasa Uchiyama, Shun Kaneko, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Shingo Furukawa, Mai Takase, Shinya Yamanaka, Kazunori Kadota …

Molecular pharmaceutics, 20(8) 4071-4085, Aug 7, 2023
Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane

Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Kunikazu Moribe

Crystal Growth & Design, Aug 2, 2023
Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles.

Naho Hanada, Kenjirou Higashi, Zhijing Zhao, Keisuke Ueda, Kunikazu Moribe

International journal of pharmaceutics, 640 122959-122959, Jun 10, 2023
脂質ナノ粒子の脂質組成と形態が免疫賦活特性に及ぼす影響(Contribution of lipid composition and morphology of lipid nanoparticle to its immunostimulatory properties)

Anindita Jessica, 田中浩揮, 山川拓真, 佐藤裕果, 石崎弘汰, 松本千佳, 植田圭祐, 東顕二郎, 森部久仁一, 佐々木香純 …

日本薬剤学会年会講演要旨集, 38年会 182-182, May, 2023
脂質ナノ粒子の脂質組成と形態が免疫賦活特性に及ぼす影響(Contribution of lipid composition and morphology of lipid nanoparticle to its immunostimulatory properties)

Anindita Jessica, 田中浩揮, 山川拓真, 佐藤裕果, 石崎弘汰, 松本千佳, 植田圭祐, 東顕二郎, 森部久仁一, 佐々木香純 …

日本薬剤学会年会講演要旨集, 38年会 182-182, May, 2023
Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin.

Mengyao Liu, Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe

International journal of pharmaceutics, 637 122876-122876, Apr 25, 2023
Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 2: Effects of Solubilizer.

Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Molecular pharmaceutics, 20(4) 1872-1883, Apr 3, 2023
Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities.

Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Molecular pharmaceutics, 20(4) 1861-1871, Apr 3, 2023
Modification of liposomes composed of a cationic lipid TMAG and an anionic lipid DSPG with a PEGylated lipid based on the investigation of lipid structures

Miyuki Hohokabe, Kenjirou Higashi, Yurina Yamada, Taiki Fujimoto, Taisei Tokumoto, Hiroshi Imamura, Takeshi Morita, Keisuke Ueda, Waree Limwikrant, Kunikazu Moribe

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 661 130891-130891, Mar, 2023

Books and Other Publications

【医薬品の原薬・添加剤の安定供給と最新技術】添加剤による難水溶性薬物の溶解性改善基礎理論と最近の研究紹介

東顕二郎, 植田圭祐, 森部久仁一

(株)じほう, Apr, 2023
結晶状態の評価法—Evaluation Methodology for Crystalline State of Drug Substance—製剤試験特集

植田圭祐

東京 : 製剤機械技術学会, 2023
液-液相分離現象を活用した超難溶性薬物の経口製剤化

植田圭祐

東京 : 上原記念生命科学財団, 2023
Evaluation Methodology for Crystalline State of Drug Substance

植田圭祐

2023
Solubility improvement of poorly water-soluble drugs by additives~basic theory and introduction of recent study~

東顕二郎, 植田圭祐, 森部久仁一

2023
Development of Amorphous Drug Nanoparticle-Forming Solid Dispersion Formulations

植田圭祐

2023
In-situ Characterization of Nano-Formulations by Atomic Force Microscopy (AFM)

植田圭祐, 菅澤祐昭, 東顕二郎, 森部久仁一

2023
超難水溶性薬物の経口製剤化を目的としたとした薬物濃縮型ナノコロイド製剤の開発

植田圭祐

千葉医学会, Dec, 2022
超難水溶性薬物の経口製剤化を目的とした薬物濃縮型ナノコロイド製剤の開発

植田圭祐

千葉医学会, 2022
The 37^th Annual Meeting of the Japan Society of Drug Delivery System

Ueda Keisuke

THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, Sep 25, 2021
座談会海外留学を経験して -若手研究者が語る新しい視点での研究生活のすすめ

松波研作, 岡本侑子, 田上辰秋, 植田圭祐, 竹内洋文

PHARM TECH JAPAN じほう, May, 2021
フォーカスグループのこれまでの軌跡と今後の展望経口吸収FG

柏倉康治, 上林敦, 白坂善之, 小嶌隆史, 植田圭祐

(公社)日本薬剤学会, Apr, 2021
第37回日本DDS学会学術集会（印象記）

Drug Delivery System, 2021
Liquid-Liquid Phase Separation in Drug-Supersaturated Solution and Formation of Drug-Rich Amorphous Nanodroplets (2)

植田圭祐

2021
Mechanistic elucidation of effect of pharmaceutical additives on amorphous drug solubility

植田圭祐

Sep, 2020
Effect of Salts on Solubility, Absorption and Stability of Food Ingredients Evaluated by Noninvasive Analytical Methods

森部久仁一, 東顕二郎, 植田圭祐

2020
Liquid-Liquid Phase Separation in Drug-Supersaturated Solution and Formation of Drug-Rich Amorphous Nanodroplets (1)

植田圭祐

2020
Design Features in the Molecular-level Development of Solid Pharmaceutical Formulations Based on Supramolecular Structures

東顕二郎, 植田圭祐, 森部久仁一

Feb, 2019
アミロースの立体構造制御による香気成分の放出制御及び固体NMR測定を利用した放出制御機構の解明

植田圭祐

2019
薬物過飽和溶液における薬物相分離および薬物吸収への影響

植田圭祐

日本DDS学会, Sep, 2018

Presentations

197

実験及び計算手法を併用したEudragit Eによる薬物可溶化機構の解明

齊藤智輝, 植田圭祐, 東顕二郎, 奥脇弘次, 古石誉之, 福澤薫, 米持悦生, 森部久仁一

日本薬剤学会年会講演要旨集, May, 2024, (公社)日本薬剤学会
Thermodynamic analysis of effect of a second drug on amorphous solubility of ritonavir

植田圭祐, 金子舜, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
リポソームへのdoxorubicin封入率にPEG修飾が及ぼす影響の評価

藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一

KEK Proceedings (Web), 2024
Evaluation of mechanical property of irinotecan-loaded liposomes using atomic force microscopy

喜田浩平, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
Drug encapsulation into lipid/γ-cyclodextrin thermoresponsive nanoparticles

関優太, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
Mechanistic investigation of morphological changes of doxorubicin-loaded liposomes by PEG modification

藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
Effect of ionizable lipids on pH-dependent structured changes of lipid nanoparticles

酒川優泉, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
Elucidation of felodipine crystallization inhibition mechanism by second drug mixing using solid-state NMR relaxation time measurements

菅原日向, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2024
Evaluation of the localization of PEG modified to the liposome interface by solution state ¹H NMR spectroscopy

東顕二郎, 仲村美咲, 植田圭祐, 森部久仁一

日本薬学会年会要旨集(Web), 2024
脂質ナノ粒子の脂質組成と形態が免疫刺激特性に関与する(Lipid composition and morphology of lipid nanoparticle contributed to its immunostimulatory properties)

アニンディタ・ジェシカ, 田中浩揮, 植田圭祐, 東顕二郎, 森部久仁一, 佐々木香純, 米持悦生, 櫻井遊, 秋田英万

日本DDS学会学術集会プログラム予稿集, Jul, 2023, 日本DDS学会
NMRを用いた脂質ナノ粒子への核酸封入機構の解明

植田圭祐, 西村公樹, 武田純平, 新井勇太, 山本克彦, 池田幸弘, 東顕二郎, 森部久仁一

日本DDS学会学術集会プログラム予稿集, Jul, 2023, 日本DDS学会
Investigating the inhibition effect of carvedilol crystallization by CD derivatives

LIU Mengyao, 植田圭祐, 東顕二郎, 森部久仁一

シクロデキストリンシンポジウム講演要旨集, 2023
Prediction of physical stability for amorphous estradiol based on molecular mobility

原脩祐, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会年会要旨集(Web), 2023
Evaluation of morphology and molecular state of doxorubicin-loaded liposome during cooling process using in situ X-ray scattering

徳本大成, 植田圭祐, 東顕二郎, 小坂井賢太, 田口宗孝, 大坂恵一, 岩尾康範, 森部久仁一

日本薬学会年会要旨集(Web), 2023
異なる薬物の共存がritonavirの液-液相分離及び非晶質溶解度に与える影響の評価

金子舜, 植田圭祐, 東顕二郎, 森部久仁一

製剤と粒子設計シンポジウム講演要旨集, 2023
溶液NMRによる薬物過飽和溶解領域の定量的解析

植田圭祐, 東顕二郎, 森部久仁一

製剤と粒子設計シンポジウム講演要旨集, 2023
液-液相分離現象を活用した超難溶性薬物の経口製剤化

植田圭祐

上原記念生命科学財団研究報告集(CD-ROM), 2023
分子動力学計算を用いたEudragit Eによる薬物可溶化機構の解明

齊藤智輝, 植田圭祐, 東顕二郎, 奥脇弘次, 古石誉之, 福澤薫, 福澤薫, 米持悦生, 森部久仁一

日本薬学会関東支部大会講演要旨集(CD-ROM), 2023
溶液¹H NMRによるナノエマルション中の薬物封入状態の定量的評価

富田紗枝子, 砂塚祐志, 植田圭祐, 東顕二郎, 森部久仁一

日本薬学会関東支部大会講演要旨集(CD-ROM), 2023
ナノ製剤の品質評価基盤を支える粒子径評価技術

植田圭祐

日本薬学会関東支部大会講演要旨集(CD-ROM), 2023

Research Projects

Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2028
Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
NMR及び液中AFMを用いたmRNA封入脂質ナノ粒子製剤品質評価技術の開発

令和5年度医療・医薬アーリーシーズ研究助成, 千葉大学未来医療教育研究機構プログラム, 2023
難溶性OTC医薬品の製剤特性改善を目的とした薬物非晶質ナノ粒子形成型固形製剤開発

令和５年度調査・研究助成, 一般用医薬品セルフメディケーション振興財団, 2023
Development of drug-rich phase-forming solid dispersion formulations based on molecular-level characterization by NMR

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Ueda Keisuke
Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Higashi Kenjirou
超難水溶性薬物の経口製剤化を目的としたとした薬物濃縮型ナノコロイド製剤の開発

2021年度猪之鼻奨学会研究助成金(若手の部), 猪之鼻奨学会, 2021
液-液相分離現象を活用した超難溶性薬物の経口製剤化

2021年度研究奨励金, 上原記念生命科学財団, 2021
難溶性ペプチド医薬品の経口製剤化を目的とした界面活性剤フリーな薬物濃縮ナノコロイド化技術の基盤構築

２０２１年度研究助成, 持田記念医学薬学振興財団, 2021
薬物非晶質ナノ粒子形成型固体分散体製剤の開発

令和２年度研究助成, ホソカワ粉体工学振興財団, 2020
Refined structural analysis and mechanical property of drug nano-formulation by AFM in aqueous meida

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MORIBE KUNIKAZU
Development of drug amorphous/nanocrystal hybrid formulation based on the molecular-level evaluation by solid-state NMR

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Ueda Keisuke, Moribe Kunikazu, Higashi Kenjirou
アミロースの立体構造制御による香気成分の放出制御及び固体NMR測定を利用した放出制御機構の解明

平成３０年度(第２５回) 研究助成, 日本食品化学研究振興財団, 2018
加熱溶融混練・アニール連続処理による高品質なOTC薬物ナノ結晶製剤調製法の確立

平成30年度調査・研究助成, 一般用医薬品セルフメディケーション振興財団, 2018
固体分散体による難水溶性薬物の溶解性改善メカニズムの解明及び処方最適化

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, Apr, 2014 - Mar, 2015

植田圭祐

Industrial Property Rights

特許第7075585号ナノ粒子複合体及びその製造方法

森部久仁一, 東顕二郎, 植田圭祐, 石本有紗, 笹子浩史, 神山和夫
特許第6867035号結晶質薬物ナノ粒子の製造方法

東顕二郎, 尾曲克彦, 植田圭祐, 森部久仁一
特開2019-189527 ナノ粒子複合体及びその製造方法

森部久仁一, 東顕二郎, 植田圭祐, 石本有紗, 笹子浩史, 神山和夫
WO2017-098729 結晶質薬物ナノ粒子の製造方法

東顕二郎, 尾曲克彦, 植田圭祐, 森部久仁一

Academic Activities

Editorial Advisory Board (EAB) member of "Molecular Pharmaceutics"

Peer review

2022 - Present
Guest Editor of "Lynne Taylor Dedicated Issue of JPharmSci"

Supervision (editorial), Review, evaluation, Peer review

2024
Guest Editor of a special issue titled "Advances in Molecular Pharmaceutical Research from Asia." in journal Molecular Pharmaceutics

Supervision (editorial), Review, evaluation, Peer review

2023

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