YAMAMOTO KEI

J-GLOBAL         Last updated: Jun 23, 2019 at 15:46
 
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Name
YAMAMOTO KEI
Affiliation
The University of Tokushima

Published Papers

 
Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics.
Murakami, M., Yamamoto, K., Taketomi, Y.
Inflammation and Regeneration   38 31   Dec 2018   [Refereed]
Izumi Tsukayama, Keisuke Toda, Yasunori Takeda, Takuto Mega, Mitsuki Tanaka, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Kei Yamamoto, Yoshimi Miki, Makoto Murakami, Toshiko Suzuki-Yamamoto
Journal of Clinical Biochemistry and Nutrition   62 139-147   Mar 2018   [Refereed]
© 2018 JCBN. Hyperproduced prostaglandin E2by cyclooxygenase-2 and micro somal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that Dioscorea japonica ex...
Makoto Murakami, Yoshimi Miki, Hiroyasu Sato, Remi Murase, Yoshitaka Taketomi, Kei Yamamoto
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids   1864(6) 803-818   Jan 2019   [Refereed]
© 2018 Elsevier B.V. Among the 11 members of the secreted phospholipase A2(sPLA2) family, group IID, IIE, IIF and III sPLA2s (sPLA2-IID, -IIE, -IIF and -III, respectively) are “new” isoforms in the history of sPLA2research. Relative to the better ...
Remi Murase, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Moe Saito, Kiyoko Fukami, Kei Yamamoto, Makoto Murakami
Scientific Reports   7 12261   Dec 2017   [Refereed]
© 2017 The Author(s). Lipid mediators play pivotal roles in colorectal cancer and colitis, but only a limited member of the phospholipase A2(PLA2) subtypes, which lie upstream of various lipid mediators, have been implicated in the positive or neg...
K. Yamamoto, Y. Miki, H. Sato, R. Murase, Y. Taketomi, M. Murakami, M. Murakami
Methods in Enzymology   583 101-117   Jan 2017   [Refereed]
© 2017 Elsevier Inc. The secreted phospholipase A2(sPLA2) family contains 10 catalytically active isoforms. Current in vitro biochemical studies have shown that individual sPLA2s have distinct substrate selectivity in terms of the polar head group...
Atsushi Irie, Kei Yamamoto, Yoshimi Miki, Makoto Murakami
Scientific Reports   7 46715   Jan 2017   [Refereed]
© The Author(s) 2017. Osteoclasts, responsible for bone resorption, are multinucleated cells formed by cell-cell fusion of mononuclear pre-osteoclasts. Although osteoclast fusion is a pivotal step for osteoclastogenesis, little is known about the ...
Hiroki Tanigawa, Keishi Miyata, Zhe Tian, Jun Aoi, Tsuyoshi Kadomatsu, Satoshi Fukushima, Aki Ogata, Naoki Takeda, Jiabin Zhao, Shunshun Zhu, Kazutoyo Terada, Motoyoshi Endo, Jun Morinaga, Taichi Sugizaki, Michio Sato, Masaki Suimye Morioka, Ichiro Manabe, Youichi Mashimo, Akira Hata, Yoshitaka Taketomi, Kei Yamamoto, Makoto Murakami, Kimi Araki, Masatoshi Jinnin, Hironobu Ihn, Yuichi Oike
Scientific Reports   6 34890   Oct 2016   [Refereed]
© The Author(s) 2016. Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evalu...
Kei Yamamoto, Yoshimi Miki, Hiroyasu Sato, Yasumasa Nishito, Michael H. Gelb, Yoshitaka Taketomi, Makoto Murakami
Journal of Biological Chemistry   291 15602-15613   Jul 2016   [Refereed]
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Recent studies using knock-out mice for various secreted phospholipase A2(sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin...
Yoshimi Miki, Yuh Kidoguchi, Mariko Sato, Yoshitaka Taketomi, Choji Taya, Kazuaki Muramatsu, Michael H. Gelb, Kei Yamamoto, Makoto Murakami
Journal of Biological Chemistry   291 15588-15601   Jul 2016   [Refereed]
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Phospholipase A2enzymes have long been implicated in the promotion of inflammation by mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they a...
Remi Murase, Hiroyasu Sato, Kei Yamamoto, Ayako Ushida, Yasumasa Nishito, Kazutaka Ikeda, Tetsuyuki Kobayashi, Toshinori Yamamoto, Yoshitaka Taketomi, Makoto Murakami
Journal of Biological Chemistry   291 6895-6911   Mar 2016   [Refereed]
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. Within the secreted phospholipase A2 (sPLA2) family, group X sPLA2 (sPLA2-X) has the highest capacity to hydrolyze cellular membranes and has long ...
M. Murakami, K. Yamamoto, Y. Miki, R. Murase, H. Sato, Y. Taketomi
Advances in Immunology   132 91-134   Jan 2016   [Refereed]
© 2016 Elsevier Inc. Within the phospholipase A2(PLA2) family that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, secreted PLA2(sPLA2) enzymes comprise the largest group containing 11 isoforms in mammals. Individual sPLA2s ex...
Kei Yamamoto
Seikagaku   88 786-790   Jan 2016   [Refereed]
Makoto Murakami, Hiroyasu Sato, Yoshimi Miki, Kei Yamamoto, Yoshitaka Taketomi
Journal of Lipid Research   56 1248-1261   Jul 2015   [Refereed]
Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. Among more than 30 members of the phospholipase A2(PLA2) superfamily, secreted PLA2(sPLA2) enzymes represent the largest family, being Ca2+-dependent low-molecul...
Rahul Vijay, Xiaoyang Hua, David K. Meyerholz, Yoshimi Miki, Kei Yamamoto, Michael Gelb, Makoto Murakami, Stanley Perlman, Stanley Perlman
Journal of Experimental Medicine   212 1851-1868   Jan 2015   [Refereed]
© 2015 Vijay et al. Oxidative stress and chronic low-grade inflammation in the lungs are associated with aging and may contribute to age-related immune dysfunction. To maintain lung homeostasis, chronic inflammation is countered by enhanced expres...
Kei Yamamoto, Yoshimi Miki, Mariko Sato, Mariko Sato, Yoshitaka Taketomi, Yasumasa Nishito, Choji Taya, Kazuaki Muramatsu, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Naotomo Kambe, Kenji Kabashima, Gérard Lambeau, Michael H. Gelb, Makoto Murakami.
Journal of Experimental Medicine   212 1901-1919   Jan 2015   [Refereed]
© 2015 Yamamoto et al. Epidermal lipids are important for skin homeostasis. However, the entire picture of the roles of lipids, particularly nonceramide lipid species, in epidermal biology still remains obscure. Here, we report that PLA2G2F, a fun...
Hiroyasu Sato, Yoshitaka Taketomi, Ayako Ushida, Yuki Isogai, Takumi Kojima, Tetsuya Hirabayashi, Yoshimi Miki, Kei Yamamoto, Yasumasa Nishito, Tetsuyuki Kobayashi, Kazutaka Ikeda, Ryo Taguchi, Shuntaro Hara, Satoshi Ida, Yuji Miyamoto, Masayuki Watanabe, Hideo Baba, Keishi Miyata, Yuichi Oike, Michael H. Gelb, Makoto Murakami.
Cell Metabolism   20 119-132   Jul 2014   [Refereed]
Metabolic disorders, including obesity and insulin resistance, have their basis in dysregulated lipid metabolism and low-grade inflammation. In a microarray search of unique lipase-related genes whose expressions are associated with obesity, we fo...
Makoto Murakami, Yoshitaka Taketomi, Yoshimi Miki, Hiroyasu Sato, Kei Yamamoto, Gérard Lambeau
Biochimie   107 105-113   Jan 2014   [Refereed]
© 2014 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). Within the phospholipase A2(PLA2) superfamily, secreted PLA2(sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conse...
Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, Hiroyasu Sato, Remi Murase, Kei Yamamoto, Satoshi Tanaka, Mariko Sakanaka, Masanori Nakamura, Yasumasa Nishito, Momoko Kawana, Naotomo Kambe, Kazutaka Ikeda, Ryo Taguchi, Satoshi Nakamizo, Kenji Kabashima, Michael H. Gelb, Makoto Arita, Takehiko Yokomizo, Motonao Nakamura, Kikuko Watanabe, Hiroyuki Hirai, Masataka Nakamura, Yoshimichi Okayama, Chisei Ra, Kosuke Aritake, Yoshihiro Urade, Kazushi Morimoto, Yukihiko Sugimoto, Takao Shimizu, Shuh Narumiya, Shuntaro Hara, Makoto Murakami
Nature Immunology   14 554-563   Jun 2013   [Refereed]
Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. Here w...
Yoshimi Miki, Kei Yamamoto, Yoshitaka Taketomi, Hiroyasu Sato, Kanako Shimo, Tetsuyuki Kobayashi, Yukio Ishikawa, Toshiharu Ishii, Hiroki Nakanishi, Kazutaka Ikeda, Ryo Taguchi, Kenji Kabashima, Makoto Arita, Hiroyuki Arai, Gérard Lambeau, James M. Bollinger, Shuntaro Hara, Michael H. Gelb, Makoto Murakami.
Journal of Experimental Medicine   210 1217-1234   Jun 2013   [Refereed]
Resolution of inflammation is an active process that is mediated in part by antiinflammatory lipid mediators. Although phospholipase A2(PLA2) enzymes have been implicated in the promotion of inflammation through mobilizing lipid mediators, the mol...
Hafid Ait-Oufella, Olivier Herbin, Christelle Coatrieux, Xavier Loyer, Jeremie Joffre, Ludivine Laurans, Bhama Ramkhelawon, Olivier Blanc-Brude, Sonia Karabina, Christophe A. Girard, Christine Payré, Kei Yamamoto, Christoph J. Binder, Makoto Murakami, Alain Tedgui, Gérard Lambeau, Ziad Mallat.
Arteriosclerosis, Thrombosis, and Vascular Biology   33 466-473   Mar 2013   [Refereed]
Objective-Several secreted phospholipases A2 (sPLA2s), including group IIA, III, V, and X, have been linked to the development of atherosclerosis, which led to the clinical testing of A-002 (varespladib), a broad sPLA2 inhibitor for the treatment ...
Kei Yamamoto, Makoto Murakami
Seikagaku   83 449-461   Dec 2011   [Refereed]
Noriko Ueno, Yoshitaka Taketomi, Kei Yamamoto, Tetsuya Hirabayashi, Daisuke Kamei, Yoshihiro Kita, Takao Shimizu, Koei Shinzawa, Yoshihide Tsujimoto, Kazutaka Ikeda, Ryo Taguchi, Makoto Murakami.
Journal of Biological Chemistry   286 37249-37263   Oct 2011   [Refereed]
Mast cells release a variety of mediators, including arachidonic acid (AA) metabolites, to regulate allergy, inflammation, and host defense, and their differentiation and maturation within extravascular microenvironments depend on the stromal cyto...
Makoto Murakami, Yoshitaka Taketomi, Hiroyasu Sato, Kei Yamamoto
Journal of Biochemistry   150 233-255   Sep 2011   [Refereed]
Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 enzymes that possess PLA2 or related activity have been identified in mammals. About one...
Kei Yamamoto, Yuki Isogai, Hiroyasu Sato, Yoshitaka Taketomi, Makoto Murakami
Analytical and Bioanalytical Chemistry   400 1829-1842   Jun 2011   [Refereed][Invited]
Phospholipase A2(PLA2) is a group of enzymes that hydrolyze the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Of many PLA2s or related enzymes identified to date, secreted PLA2s (sPLA2s) comprise the largest fam...
Hiroyasu Sato, Yuki Isogai, Seiko Masuda, Yoshitaka Taketomi, Yoshimi Miki, Daisuke Kamei, Shuntaro Hara, Tetsuyuki Kobayashi, Yukio Ishikawa, Toshiharu Ishii, Kazutaka Ikeda, Ryo Taguchi, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Toshiko Suzuki-Yamamoto, Kei Yamamoto, Makoto Murakami.
Journal of Biological Chemistry   286 11632-11648   Apr 2011   [Refereed]
Although the secreted phospholipase A2(sPLA2) family has been generally thought to participate in pathologic events such as inflammation and atherosclerosis, relatively high and constitutive expression of group X sPLA2(sPLA2-X) in restricted sites...
Kei Yamamoto, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Hiroyasu Sato, Seiko Masuda, Yasumasa Nishito, Kiyokazu Morioka, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kiyoko Fukami, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Makoto Murakami
Journal of Biological Chemistry   286 11616-11631   Apr 2011   [Refereed]
Although perturbed lipid metabolism can often lead to skin abnormality, the role of phospholipase A2 (PLA2) in skin homeostasis is poorly understood. In the present study we found that group X-secreted PLA 2 (sPLA2-X) was expressed in the outermos...
Makoto Murakami, Yoshitaka Taketomi, Yoshimi Miki, Hiroyasu Sato, Tetsuya Hirabayashi, Kei Yamamoto
Progress in Lipid Research   50 152-192   Apr 2011   [Refereed]
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or related enzymes, which are subdivided into several classes including low-molecular-weight secreted PLA2s (sPLA2s), Ca2+-dependent cytosolic PLA2s (cPLA2s), Ca2+-independe...
Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi, Kei Yamamoto
International Journal of Molecular Sciences   12 1474-1495   Mar 2011   [Refereed]
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or related enzymes, which are infdivided into several infgroups based on their structures, catalytic mechanisms, localizations and evolutionary relationships. More than one ...
Makoto Murakami, Yoshitaka Taketomi, Christophe Girard, Kei Yamamoto, Gérard Lambeau
Biochimie   92 561-582   Jun 2010   [Refereed]
Among the emerging phospholipase A2(PLA2) superfamily, the secreted PLA2(sPLA2) family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp catalytic dyad. To date, more than 10 sPLA2enzymes have been identified in m...
Hiroyasu Sato, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Kei Yamamoto, Seiko Masuda, Tomohiko Hosono, Satoru Arata, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Hiroki Nakanishi, Kazutaka Ikeda, Ryo Taguchi, Shuntaro Hara, Ichiro Kudo, Makoto Murakami.
Journal of Clinical Investigation   120 1400-1414   May 2010   [Refereed]
Although lipid metabolism is thought to be important for the proper maturation and function of spermatozoa, the molecular mechanisms that underlie this dynamic process in the gonads remains incompletely understood. Here, we show that group III pho...
Jessica Escoffier, Ikram Jemel, Akemi Tanemoto, Yoshitaka Taketomi, Christine Payre, Christelle Coatrieux, Hiroyasu Sato, Kei Yamamoto, Seiko Masuda, Karin Pernet-Gallay, Virginie Pierre, Shuntaro Hara, Makoto Murakami, Michel De Waard, Gérard Lambeau, Christophe Arnoult.
Journal of Clinical Investigation   120 1415-1428   May 2010   [Refereed]
Ejaculated mammalian sperm must undergo a maturation process called capacitation before they are able to fertilize an egg. Several studies have suggested a role for members of the secreted phospholipase A2(sPLA2) family in capacitation, acrosome r...
Yukio Ishikawa, Masayo Kimura-Matsumoto, Makoto Murakami, Kei Yamamoto, Yoshikiyo Akasaka, Miwa Uzuki, Yuri Yuri, Naomi Inomata, Tomoko Yokoo, Toshiharu Ishii
Journal of atherosclerosis and thrombosis   16 829-839   Dec 2009   [Refereed]
AIM: Scavenger receptors type I and II (SRBI/II) have dual roles in both atherogenic and antiatherogenic functions through interactions with lipoproteins and their expression in macrophages; how-ever, the distribution and density of SRBI/II-positi...
Hiroyasu Sato, Yoshitaka Taketomi, Yuki Isogai, Seiko Masuda, Tetsuyuki Kobayashi, Kei Yamamoto, Makoto Murakami.
Biochemical Journal   421 17-27   Jul 2009   [Refereed]
PLA2(phospholipase A2) group III is an atypical sPLA2(secretory PLA2) that is homologous with bee venom PLA2rather than with other mammalian sPLA2s. In the present paper, we show that endogenous group III sPLA2(PLA2G3) is expressed in mouse skin a...
Hiroyasu Sato, Rina Kato, Yuki Isogai, Go Ichi Saka, Mitsuhiro Ohtsuki, Yoshitaka Taketomi, Kei Yamamoto, Kae Tsutsumi, Joe Yamada, Seiko Masuda, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kazutaka, Ryo Taguchi, Shinji Hatakeyama, Shuntaro Hara, Ichiro Kudo, Hiroyuki Itabe, Makoto Murakami.
Journal of Biological Chemistry   283 33483-33497   Nov 2008   [Refereed]
Among the many mammalian secreted phospholipase A2(sPLA2) enzymes, PLA2G3 (group III secreted phospholipase A2) is unique in that it possesses unusual N- and C-terminal domains and in that its central sPLA2domain is homologous to bee venom PLA2rat...
Seiko Masuda, Kei Yamamoto, Tetsuya Hirabayashi, Yukio Ishikawa, Toshiharu Ishii, Ichiro Kudo, Makoto Murakami.
Biochemical Journal   409 429-438   Jan 2008   [Refereed]
Human sPLA2-III [group III secreted PLA2 (phospholipase A2)] is an atypical sPLA2 isoenzyme that consists of a central group III sPLA2 domain flanked by unique N- and C-terminal domains. In the present study, we found that sPLA2-III is expressed i...
Mitsuhiro Ohtsuki, Yoshitaka Taketomi, Satoru Arata, Seiko Masuda, Yukio Ishikawa, Toshiharu Ishii, Yasukazu Takanezawa, Junken Aoki, Hiroyuki Arai, Kei Yamamoto, Ichiro Kudo, Makoto Murakami.
Journal of Biological Chemistry   281 36420-36433   Nov 2006   [Refereed]
In an effort to elucidate the functions of secreted phospholipase A2(sPLA2) enzymes in vivo, we generated transgenic (Tg) mice for group V sPLA2(sPLA2-V) and group X sPLA2(sPLA2-X), which act potently on phosphatidylcholine in vitro. We found that...
Kei Yamamoto, Jining Wang, Shozo Yamamoto, Hiroyasu Tobe
Advances in Experimental Medicine and Biology   507 73-77   Dec 2002   [Refereed]
Kotoku Kurachi, Kezhong Zhang, Jeffrey Huo, Afshin Ameri, Mitsuhiro Kuwahara, Jean Marc Fontaine, Kei Yamamoto, Sumiko Kurachi
Physica A: Statistical Mechanics and its Applications   315 105-113   Nov 2002   [Refereed]
Through systematic studies of pro- and anti-blood coagulation factors, we have determined molecular mechanisms involving two genetic elements, age-related stability element (ASE), GAGGAAG and age-related increase element (AIE), a unique stretch of...
Mariko Shimamura, Tadahiko Hazato, Hiromi Ashino, Yukio Yamamoto, Eri Iwasaki, Hiroyasu Tobe, Kei Yamamoto, Shozo Yamamoto
Biochemical and Biophysical Research Communications   289 220-224   Nov 2001   [Refereed]
On the basis of our previous finding that humulone, a bitter acid from beer hop extract, was a potent inhibitor of bone resorption and inhibited the catalytic activity of cyclooxygenase-2 (COX-2) and more potently the transcription of the COX-2 ge...
Hiroyoshi Sei, Daisuke Saitoh, Kei Yamamoto, Kyoji Morita, Yusuke Morita
Brain Research   877 387-390   Sep 2000   [Refereed]
It is well known that REM sleep is associated with memory consolidation, especially, procedural skill learning. Neurotrophic factors are known to be involved in synaptic plasticity. We therefore investigated the effects of selective REM sleep depr...
Kei Yamamoto, Jining Wang, Shozo Yamamoto, Hiroyasu Tobe
FEBS Letters   465 103-106   Jan 2000   [Refereed]
In murine osteoblastic MC3T3-E1 cells which produced prostaglandin E2 as a bone resorption factor, the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) was suppressed by dexamethasone with an IC50of 1 nM. Humulon isolated from hop extr...
Shozo Yamamoto, Natsuo Ueda, Ishtiaq Mahmud, Hiroko Yamaguchi, Rieko Yamashita, Kei Yamamoto, Kazunori Ishimura, Yoshihiro Urade, Yoshihide Kanaoka, Osamu Hayaishi
Advances in Experimental Medicine and Biology   469 17-21   Jan 2000   [Refereed]
Kazuhito Tsuboi, Yukihiko Sugimoto, Aya Iwane, Kei Yamamoto, Shozo Yamamoto, Atsushi Ichikawa, Atsushi Ichikawa
Endocrinology   141 315-324   Jan 2000   [Refereed]
PG production in uterine tissues is important for many physiological processes in late pregnancy, including parturition. We examined the expression of the PGH2synthases, cyclooxygenase-1 (COX-1) and COX-2, in uterine tissues during late pregnancy,...
Shozo Yamamoto, Natsuo Ueda, Ishtiaq Mahmud, Hiroko Yamaguchi, Rieko Yamashita, Kei Yamamoto, Kazunori Ishimura, Yoshihiro Urade, Yoshihide Kanaoka, Osamu Hayaishi
BioFactors   11 57-61   Jan 2000   [Refereed]
Jining Wang, Kei Yamamoto, Yukihiko Sugimoto, Atsushi Ichikawa, Shozo Yamamoto
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids   1441 69-76   Oct 1999   [Refereed]
Mouse osteoblastic cells MC3T3-E1 produced prostaglandin E2via the reaction of cyclooxygenase-2 enzyme induced by tumor necrosis factor α (TNFα). Originally, the mRNA level for prostaglandin I2receptor (IP) was low in the cells. However, the addit...
S. Yamamoto, S. Yamamoto, K. Yamamoto, H. Kurobe, R. Yamashita, H. Yamaguchi, N. Ueda
International Journal of Tissue Reactions   20 17-22   Dec 1998   [Refereed]
Transcriptional regulation of fatty acid cyclooxygenase isozymes (COX-1 and COX-2) were studied using two cell lines. A rapid and transient induction of COX-2 was observed by the addition of tumor necrosis factor α (TNFα) to murine osteoblastic ce...
Kei Yamamoto, Hirotsugu Kurobe, Shozo Yamamoto
FASEB Journal   11    Dec 1997   [Refereed]
Fatty acid cyclooxygenase-2 (COX-2) is induced by various hormones, cytokines, and prostaglandins (PGs) in a mouse osteoblastic cell line MC3T3-E1. The induction of the enzyme is suppressed by glucocorticoid. Recently we found a rapid and transien...
Kei Yamamoto, Toshiya Arakawa, Yutaka Taketani, Yoshitaka Takahashi, Yoko Hayashi, Natsuo Ueda, Shozo Yamamoto, Masayoshi Kumegawa
Advances in Experimental Medicine and Biology   407 185-189   Dec 1996   [Refereed]
Natsuo Ueda, Yuko Kurahashi, Kei Yamamoto, Shozo Yamamoto
Advances in Experimental Medicine and Biology   407 323-328   Dec 1996   [Refereed]
Toyoshi Katagi, Hiromi Kataoka, Yuriko Konishi, Yuki Takata, Sachiyo Kitano, Masae Yamaki, Takeshi Inoi, Kei Yamamoto, Shozo Yamamoto, Yuriko Yamagata
Chemical and Pharmaceutical Bulletin   44 145-149   Jan 1996   [Refereed]
Novel O-acyloximes having an acetyl group or N-protected amino acid as an O-acyl group were synthesized by reaction with acetyl chloride or by a mixed anhydride method. 4'-Morpholinoacetophenone oxime (oxime-2) was determined to be the (E) isomer ...
Natsuo Ueda, Yuko Kurahashi, Kei Yamamoto, Shozo Yamamoto, Takashi Tokunaga
Journal of Lipid Mediators and Cell Signalling   14 57-61   Jan 1996   [Refereed]
Anandamide is an endogenous ligand for cannabinoid receptors. We tried to isolate and purify 'anandamide amidohydrolase' which hydrolyzes anandamide to arachidonic acid and ethanolamine. The enzyme activity was found in the microsomal fraction of ...
H. Ikawa, K. Yamamoto, Y. Takahashi, N. Ueda, Y. Hayashi, S. Yamamoto, K. Ishimura, M. Irahara, T. Aono
Journal of Endocrinology   148 33-41   Jan 1996   [Refereed]
Arachidonate 12-lipoxygenase, which oxygenates positions 12 and 13 of arachidonic and linoleic acids, is present in porcine anterior pituitary cells. Colocalization of the 12-lipoxygenase with various pituitary hormones was examined by immunohisto...
Yoshiteru Harada, Yoshiteru Harada, Ko Hatanaka, Ko Hatanaka, Michiko Kawamura, Michiko Kawamura, Maki Saito, Maki Saito, Michiko Ogino, Michiko Ogino, Masataka Majima, Masataka Majima, Takashi Ohno, Takashi Ohno, Keiko Ogino, Keiko Ogino, Kei Yamamoto, Kei Yamamoto, Yutaka Taketani, Yutaka Taketani, Shozo Yamamoto, Shozo Yamamoto, Makoto Katori, Makoto Katori
Prostaglandins   51 19-33   Jan 1996   [Refereed]
Rat carrageenin-induced pleurisy was used to clarify the role of prostaglandin H synthase (PGHS)-2 in acute inflammation. Intrapleural injection of 0.2 ml of 2% λ-carrageenin induced accumulation of exudate and infiltration of leukocytes into the ...
Kei Yamamoto, Toshiya Arakawa, Natsuo Ueda, Shozo Yamamoto
Journal of Biological Chemistry   270 31315-31320   Dec 1995   [Refereed]
When a mouse osteoblastic cell line MC3T3-E1 was cultured in the presence of tumor necrosis factor α (TNFα), the release of prostaglandin E2and the cyclooxygenase activity increased in a dose- and time-dependent manner. The increase of the enzyme ...
Natsuo Ueda, Kei Yamamoto, Shozo Yamamoto, Takashi Tokunaga, Eiji Shirakawa, Hisashi Shinkai, Masako Ogawa, Taku Sato, Ichiro Kudo, Keizo Inoue, Hiromasa Takizawa, Tatsuo Nagano, Masaaki Hirobe, Norio Matsuki, Hiroshi Saito
Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism   1254 127-134   Jan 1995   [Refereed]
Various purified lipoxygenases were incubated with [14C]arachidonylethanolamide which is an endogenous ligand for cannabinoid receptors. When radioactive products were analyzed by thin-layer chromatography, porcine leukocyte 12-lipoxygenase and ra...
N. Ueda, K. Yamamoto, Y. Kurahashi, S. Yamamoto, M. Ogawa, N. Matsuki, I. Kudo, H. Shinkai, E. Shirakawa, T. Tokunaga
Advances in prostaglandin, thromboxane, and leukotriene research   23 163-165   Jan 1995   [Refereed]

Conference Activities & Talks

 
Group IIF phospholipase A2/lysophosplasmalogen axis is a novel drug target for epidermal-hyperplastic diseases.
Yamamoto, K., Hakoi, H., Miki, Y., and Murakami, M.
60th International Conference on the Bioscience of Lipids.   19 Jun 2019   
Inhibition of arachidonate 5-lipoxygenase and improvement in psoriasis by red rice proanthocyanidin.
Toda, K., Nagasaki, Y., Tsukayama, I., Tamenobu, A., Konoike, Y., Ganeko, N., Ito, H., Kawakami, Y., Takahashi, Y., Miki, Y., Yamamoto, K., Murakami, M., and Suzuki-Yamamoto, T.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
Group IVE phospholipase A2 (cPLA2e) mobilizes the non-canonical lipid mediator N-acylethanolamine in mouse skin.
Liang, L., Heike, K., Kobayahsi, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Taketomi, Y., and Murakami, M.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
Distinct roles of phospholipase A2s in colitis and colonic cancer.
Murase, R., Taketomi, Y., Miki, Y, Yamamoto, K., and Murakami, M.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
Group IID phospholipase A2 promotes browning of white adipose tissue and limits obesity.
Sato, H., Taketomi, Y., Miki, Y., Yamamoto, K., and Murakami, M.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
Group IIA phospholipase A2 regulates gut microbiome.
Miki, Y., Taketomi, Y., Yamamoto, K., Hosomi, K., Kunisawa, J., Gowda, S.G..B., Ikeda, K., Arita, M., and Murakami, M.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
Exosome could be the source of lipid mediator in cancer platform.
Kudou, K., Miki, Y., Higuchi, H., Yamamoto, K., Murakami, M., and Kotani, Ai.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
The roles of lysoplasmalogen in three-dimensional keratinocyte culture system.
Hakoi, H. and Yamamoto, K.
60th International Conference on the Bioscience of Lipids.   18 Jun 2019   
The combination technology of gene-engineered mice and lipidomics elucidates new lipid pathways:Discovery of new bioactive lipid as a regulator of epidermal hyperplastic diseases. [Invited]
8 Sep 2018   
A plasmalogen- lysophosphatidylethanolamine produced by epidermal sPLA2 (PLA2G2F) is a novel regulator and drug target for epidermal-hyperplasic diseases.
YAMAMOTO KEI
Bioactive Lipids 2018. Athens, Greece   29 Mar 2018   
The technology of Lipidomics elucidates new lipid pathways: Discovery of new lysophospholipid as a regulator of epidermal hyperplastic diseases. [Invited]
YAMAMOTO KEI
National Chiayi University. Chiayi, Taiwan. Seminar.   2 Mar 2018   
The technology of Lipidomics elucidates new lipid pathways: Discovery of new lysophospholipid as a regulator of epidermal hyperplastic diseases. [Invited]
YAMAMOTO KEI
Wayne state University. Detroit, MI, USA. Seminar.   27 Oct 2017   
An epidermal sPLA2 (PLA2G2F)/plasmalogen- lysophosphatidylethanolamine axis is a novel drug target for epidermal-hyperplastic diseases.
Yamamoto, K., Fujino, S., Miki, Y., and Murakami, M.
The 15th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases. Puerto Vallarta, Mexico   22 Oct 2017   
Dual roles of group IID phospholipase A2 in inflammation and cancer.
Miki, Y., Taketomi, Y., Yamamoto, K., and Murakami, M.
The 15th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases. Puerto Vallarta, Mexico   22 Oct 2017   
Plasmalogen- lysophosphatidylethanolamine mobilized by an epidermal sPLA2 (PLA2G2F) is a novel regulator and biomarker for epidermal-hyperplasic diseases.
Yamamoto, K., Fujino, S., Miki, Y., and Murakami, M.
FASEB Summer Research Conferences on Lysophospholipid and related Mediators. New Orleans, LU, USA   20 Aug 2017   
A unique plasmalogen pathway driven by secreted phospholipase A2 regulates skin homeostasis and disease. [Invited]
Murakami, M. and Yamamoto, K.
The 1st International Plasmalogen Symposium. Fukuoka, Japan   7 Nov 2016   
Plasmalogen-lysophosphatidylethanolamine is a novel regulator and biomarker for epidermal-hyperplastic diseases. The 1st International Plasmalogen Symposium. Fukuoka, Japan
Yamamoto, K., Miki, Y., Taketomi, Y., and Murakami, M.
The 1st International Plasmalogen Symposium. Fukuoka, Japan,   7 Nov 2016   
The two secreted phospholipase A2s PLA2G2F and PLA2G2E play distinct roles in skin homeostasis and diseases.
Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Lambeau, G., Gelb, M., and Murakami, M.
7th International conference on phospholipase A2 and lipid mediators. La Jolla, USA   19 May 2016